ITGB3BP

Gene Symbol	ITGB3BP
Entrez Gene	23421
Alt Symbol	CENP-R, CENPR, HSU37139, NRIF3, TAP20
Species	Human
Gene Type	protein-coding
Description	integrin beta 3 binding protein (beta3-endonexin)
Other Description	beta 3 endonexin|beta-3-endonexin|centromere protein R|integrin beta-3-binding protein|nuclear receptor-interacting factor 3
Swissprots	Q5RJ45 Q13353 Q9UKB6 Q96CD5 Q5RJ42 Q7KYX2 B2R7D8 Q5RJ44 Q13352
Accessions	EAX06561 EAX06562 EAX06563 EAX06564 EAX06565 EAX06566 EAX06567 Q13352 AA873717 AF175306 AAF00239 AK309622 AK312944 BAG35785 BC009929 AAH09929 BC014385 AAH14385 BU853146 U37139 AAC50294 XM_006710514 XP_006710577 XM_006710515 XP_006710578 XM_011541130 XP_011539432 XM_011541131 XP_011539433 NM_001206739 NP_001193668 NM_014288 NP_055103 NR_045147
Function	Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore prote
Subcellular Location	Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.
Tissue Specificity	Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:11864709, ECO:0000269|PubMed:7593198}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CENP-R (L-18) - sc-69249 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CENP-R (S-19) - sc-69251 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CENP-R (G-78) - sc-101092 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-ITGB3BP antibody - ab182773 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITGB3BP antibody - ab82764 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITGB3BP antibody - ab57098 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ITGB3BP antibody - ab192324 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITGB3BP antibody [4H1] - ab180474 from Abcam Prices $357.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H1

Anti-ITGB3BP Antibody (aa1-100) - LS-C308545 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ITGB3BP Antibody (aa1-100, Azide-free) - LS-C327632 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-ITGB3BP Antibody - LS-C341901 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ITGB3BP Antibody (aa36-85) - LS-C81978 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ITGB3BP Antibody (clone 4H1) - LS-C336859 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H1

Anti-ITGB3BP Antibody (N-Terminus) - LS-C345520 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ITGB3BP Antibody - LS-C334331 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

NRIF3 Antibody - NBP1-85687 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NRIF3 Antibody (3F6) - H00023421-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F6

NRIF3 Antibody - NBP1-59187 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

NRIF3 Antibody - H00023421-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-ITGB3BP antibody produced in rabbit - HPA028463 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ITGB3BP antibody produced in rabbit - SAB2101184 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-ITGB3BP antibody produced in mouse - WH0023421M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F6

ITGB3BP antibody - N-terminal region (ARP54999_P050) - ARP54999_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ITGB3BP Antibody - N-terminal region (ARP55000_P050) - ARP55000_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ITGB3BP-Antibody-monoclonal-M01 - AT2569a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F6

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