ITGB3BP
| Gene Symbol | ITGB3BP |
|---|---|
| Entrez Gene | 23421 |
| Alt Symbol | CENP-R, CENPR, HSU37139, NRIF3, TAP20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin beta 3 binding protein (beta3-endonexin) |
| Other Description | beta 3 endonexin|beta-3-endonexin|centromere protein R|integrin beta-3-binding protein|nuclear receptor-interacting factor 3 |
| Swissprots | Q5RJ45 Q13353 Q9UKB6 Q96CD5 Q5RJ42 Q7KYX2 B2R7D8 Q5RJ44 Q13352 |
| Accessions | EAX06561 EAX06562 EAX06563 EAX06564 EAX06565 EAX06566 EAX06567 Q13352 AA873717 AF175306 AAF00239 AK309622 AK312944 BAG35785 BC009929 AAH09929 BC014385 AAH14385 BU853146 U37139 AAC50294 XM_006710514 XP_006710577 XM_006710515 XP_006710578 XM_011541130 XP_011539432 XM_011541131 XP_011539433 NM_001206739 NP_001193668 NM_014288 NP_055103 NR_045147 |
| Function | Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore prote |
| Subcellular Location | Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic. |
| Tissue Specificity | Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:11864709, ECO:0000269|PubMed:7593198}. |
CENP-R CRISPR/Cas9 KO Plasmid (h) - sc-416273 from Santa Cruz Biotechnology
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CENP-R HDR Plasmid (h) - sc-416273-HDR from Santa Cruz Biotechnology
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CENP-R Double Nickase Plasmid (h) - sc-416273-NIC from Santa Cruz Biotechnology
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CENP-R Double Nickase Plasmid (h2) - sc-416273-NIC-2 from Santa Cruz Biotechnology
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CENP-R CRISPR Activation Plasmid (h) - sc-416273-ACT from Santa Cruz Biotechnology
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CENP-R CRISPR Activation Plasmid (h2) - sc-416273-ACT-2 from Santa Cruz Biotechnology
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CENP-R Lentiviral Activation Particles (h) - sc-416273-LAC from Santa Cruz Biotechnology
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CENP-R Lentiviral Activation Particles (h2) - sc-416273-LAC-2 from Santa Cruz Biotechnology
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CENP-R siRNA (h) - sc-72862 from Santa Cruz Biotechnology
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CENP-R shRNA Plasmid (h) - sc-72862-SH from Santa Cruz Biotechnology
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CENP-R shRNA (h) Lentiviral Particles - sc-72862-V from Santa Cruz Biotechnology
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NRIF3 RNAi - H00023421-R01 from Novus Biologicals
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MISSION® esiRNA - EHU092721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10818 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10818 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02265 from Sigma-Aldrich
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ITGB3BP siRNA (Human) - CRH8259 from Cohesion Biosciences
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ITGB3BP - MBS8201528 from MyBioSource
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shRNA set against Human ITGB3BP (NM_014288.4) - SHH321413 from Creative biogene
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Human ITGB3BP siRNA - orb268761 from Biorbyt
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ITGB3BP shRNA Plasmid (Human) - CHH8259 from Cohesion Biosciences
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ITGB3BP miRNA 3'UTR clone - MiUTR3H-07733 from Creative biogene
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