ITGB3BP

Gene Symbol	ITGB3BP
Entrez Gene	23421
Alt Symbol	CENP-R, CENPR, HSU37139, NRIF3, TAP20
Species	Human
Gene Type	protein-coding
Description	integrin beta 3 binding protein (beta3-endonexin)
Other Description	beta 3 endonexin|beta-3-endonexin|centromere protein R|integrin beta-3-binding protein|nuclear receptor-interacting factor 3
Swissprots	Q5RJ45 Q13353 Q9UKB6 Q96CD5 Q5RJ42 Q7KYX2 B2R7D8 Q5RJ44 Q13352
Accessions	EAX06561 EAX06562 EAX06563 EAX06564 EAX06565 EAX06566 EAX06567 Q13352 AA873717 AF175306 AAF00239 AK309622 AK312944 BAG35785 BC009929 AAH09929 BC014385 AAH14385 BU853146 U37139 AAC50294 XM_006710514 XP_006710577 XM_006710515 XP_006710578 XM_011541130 XP_011539432 XM_011541131 XP_011539433 NM_001206739 NP_001193668 NM_014288 NP_055103 NR_045147
Function	Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore prote
Subcellular Location	Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.
Tissue Specificity	Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:11864709, ECO:0000269|PubMed:7593198}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ITGB3BP full length protein - ab161635 from Abcam Category Protein Source Wheat germ Species Human

Human ITGB3BP full length protein - ab156338 from Abcam Category Protein Source E. coli Species Human

Human ITGB3BP protein fragment - ab161636 from Abcam Category Protein Source Wheat germ Species Human

Human ITGB3BP protein fragment - ab161637 from Abcam Category Protein Source Wheat germ Species Human

ITGB3BP Antibody Blocking Peptide - LS-E19847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NRIF3 Recombinant Protein - H00023421-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NRIF3 Partial Recombinant Protein - H00023421-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NRIF3 Partial Recombinant Protein - H00023421-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NRIF3 Protein - NBP2-23143 from Novus Biologicals Category Protein Prices $309.00 Sizes 20 µg Species Human

Human ITGB3BP protein - orb191147 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

ITGB3BP Blocking Peptide - 33R-9096 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ITGB3BP protein (His tag) - 80R-2763 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

CENP-R / ITGB3BP (1-216, His-tag) - AR50882PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

CENP-R / ITGB3BP (1-216, His-tag) - AR50882PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

CENP-R / ITGB3BP - H00023421-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CENP-R / ITGB3BP - H00023421-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CENP-R / ITGB3BP - H00023421-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CENP-R / ITGB3BP - H00023421-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CENP-R / ITGB3BP - H00023421-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CENP-R / ITGB3BP - H00023421-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CENP-R / ITGB3BP - H00023421-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ITGB3BP, 1-216aa, Human His tag, E.coli - 01-P2058 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

Centromere protein R fusion protein - Ag1204 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Centromere protein R fusion protein - Ag18033 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant Human ITGB3BP, GST-tagged - ITGB3BP-180H from Creative Biomart Category Protein Source E.coli Species Human

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