| Gene Symbol |
ZIC3
|
| Entrez Gene |
7547
|
| Alt Symbol |
HTX, HTX1, VACTERLX, ZNF203
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Zic family member 3
|
| Other Description |
Zic family member 3 (odd-paired homolog, Drosophila)|heterotaxy 1|zinc finger protein 203|zinc finger protein ZIC 3|zinc finger protein of the cerebellum 3
|
| Swissprots |
Q5JY75 Q14DE5 B2CNW4 O60481
|
| Accessions |
EAW88447 O60481 AF028706 AAC05594 BC111854 AAI11855 BC113393 AAI13394 BC113395 AAI13396 BM667189 EU532020 ACB30403 HQ258447 ADR83201 NM_003413 NP_003404
|
| Function |
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:17764085}.
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|