ZIC3

Gene Symbol ZIC3
Entrez Gene 7547
Alt Symbol HTX, HTX1, VACTERLX, ZNF203
Species Human
Gene Type protein-coding
Description Zic family member 3
Other Description Zic family member 3 (odd-paired homolog, Drosophila)|heterotaxy 1|zinc finger protein 203|zinc finger protein ZIC 3|zinc finger protein of the cerebellum 3
Swissprots Q5JY75 Q14DE5 B2CNW4 O60481
Accessions EAW88447 O60481 AF028706 AAC05594 BC111854 AAI11855 BC113393 AAI13394 BC113395 AAI13396 BM667189 EU532020 ACB30403 HQ258447 ADR83201 NM_003413 NP_003404
Function Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:17764085}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

Zic3 (C-12) - sc-28156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zic3 (C-12): sc-28156. Western blot analysis of Zic3 expression in Y79 nuclear extract.

Zic3 (N-19) - sc-28154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zic3 (N-19): sc-28154. Western blot analysis of Zic3 expression in NIH/3T3 (A) and Rat2 (B) whole cell lysates.

Zic3 (H-67) - sc-292177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Zic3 (SQ-15) - sc-101201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Zic3 (SQ-15): sc-101201. Western blot analysis of Zic3 expression in Y79 whole cell lysate.

Anti-ZIC3 antibody - ab189969 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human Prostate tissue labeling ZIC3 with ab189969 at 5 µg/ml.

Anti-ZIC3 antibody - ab133153 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab133153 (5µg/ml) showsstaining ZOC3 in paraffin embedded Human Prostate following steamed antigen retrieval with citrate buffer pH 6 and AP-staining. This shows nuclear staining in select secretory cells.

Anti-ZIC3 antibody - ab133161 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-ZIC3 antibody - ab58318 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58318 Zic 3 antibody at 1ug/ml.

Anti-ZIC3 antibody - C-terminal - ab80966 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-ZIC3 Antibody (aa239-267) - LS-C160792 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ZIC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-ZIC3 Antibody (aa178-189) IHC-plus™ - LS-B9538 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ZIC3 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9538 concentration 5 ug/ml.

Anti-ZIC3 Antibody - LS-C11153 from LifeSpan Bioscience

Prices $435.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ZIC3 Antibody (C-Terminus) - LS-C95288 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ZIC3 Antibody (aa205-218) - LS-C154841 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ZIC3 Antibody (aa93-142) - LS-C134964 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ZIC3 antibody LS-C134964 Western blot of ACHN lysate.

Anti-ZIC3 Antibody (clone 4F7) - LS-C198455 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F7
Detection limit for recombinant GST tagged ZIC3 is approximately 10 ng/ml as a capture antibody.

Anti-ZIC3 Antibody (aa4-32) - LS-C98644 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ZIC3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

ZIC3 Antibody - AF5310 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of 293T human embryonic kidney cell line, Jurkat human acute T cell leukemia cell line, and NIH‑3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse ZIC3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5310) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for ZIC3 at approximately 56 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

ZIC3 Antibody - NBP2-33669 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ZIC3 Antibody - NBP1-33207 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZIC3 Antibody [NBP1-33207] - Sample (30 ug of whole cell lysate) A: Hep G2 10% SDS PAGE; antibody diluted at 1:500

ZIC3 Antibody (2C1) - H00007547-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1

ZIC3 Antibody (4F7) - H00007547-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F7
Western Blot: ZIC3 Antibody (3F7) [H00007547-M01] - detection against Immunogen (36.23 KDa).

Zic1/2/3 Antibody - NBP1-20238 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ZIC3 Antibody (2G1) - H00007547-M06 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G1
Western Blot: ZIC3 Antibody (2G1) [H00007547-M06] - detection against Immunogen (36.23 KDa) .

ZIC3 Antibody (4G6) - H00007547-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G6
Western Blot: ZIC3 Antibody (4G6) [H00007547-M04] - detection against Immunogen (36.23 KDa).
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