Gene Symbol | ZIC3 |
---|---|
Entrez Gene | 7547 |
Alt Symbol | HTX, HTX1, VACTERLX, ZNF203 |
Species | Human |
Gene Type | protein-coding |
Description | Zic family member 3 |
Other Description | Zic family member 3 (odd-paired homolog, Drosophila)|heterotaxy 1|zinc finger protein 203|zinc finger protein ZIC 3|zinc finger protein of the cerebellum 3 |
Swissprots | Q5JY75 Q14DE5 B2CNW4 O60481 |
Accessions | EAW88447 O60481 AF028706 AAC05594 BC111854 AAI11855 BC113393 AAI13394 BC113395 AAI13396 BM667189 EU532020 ACB30403 HQ258447 ADR83201 NM_003413 NP_003404 |
Function | Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:17764085}. |
Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |