| Gene Symbol |
LPCAT1
|
| Entrez Gene |
79888
|
| Alt Symbol |
AYTL2, PFAAP3, lpcat
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidylcholine acyltransferase 1
|
| Other Description |
1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPC acyltransferase 1|LPCAT-1|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 1|acyltransferase like 2|acyltransferase-like 2|lyso-PAF acetyltransferase|lysoPAFAT|lysoPC acyltransferase 1|phosphonoformate immuno-associated protein 3|regulated by phosphonoformate
|
| Swissprots |
Q8NF37 Q1HAQ1 Q9GZW6 Q7Z4G6 Q8WUL8 Q8N3U7
|
| Accessions |
EAX08154 EAX08155 EAX08156 Q8NF37 AB244719 BAE94688 AF052162 AF530061 AAQ09945 AK022499 BAB14061 AK022505 BAB14065 AK090444 BAC03425 AK095552 AK123603 AL831864 CAD38556 BC002543 BC020166 AAH20166 BC140367 AAI40368 BQ961819 BU539058 XM_005248373 XP_005248430 XM_011514132 XP_011512434 XM_011514133 XP_011512435 XM_011514134 XP_011512436 NM_024830 NP_079106
|
| Function |
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. {ECO:0000269|PubMed:16864775, ECO:0000269|PubMed:21498505}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
|
| Top Pathways |
Ether lipid metabolism, Glycerophospholipid metabolism
|
![Western Blot: LPCAT1 Overexpression Lysate (Adult Normal) [NBL1-12648] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LPCAT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8442_LPCAT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12648-img0002.jpg)