LPCAT1

Gene Symbol LPCAT1
Entrez Gene 79888
Alt Symbol AYTL2, PFAAP3, lpcat
Species Human
Gene Type protein-coding
Description lysophosphatidylcholine acyltransferase 1
Other Description 1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPC acyltransferase 1|LPCAT-1|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 1|acyltransferase like 2|acyltransferase-like 2|lyso-PAF acetyltransferase|lysoPAFAT|lysoPC acyltransferase 1|phosphonoformate immuno-associated protein 3|regulated by phosphonoformate
Swissprots Q8NF37 Q1HAQ1 Q9GZW6 Q7Z4G6 Q8WUL8 Q8N3U7
Accessions EAX08154 EAX08155 EAX08156 Q8NF37 AB244719 BAE94688 AF052162 AF530061 AAQ09945 AK022499 BAB14061 AK022505 BAB14065 AK090444 BAC03425 AK095552 AK123603 AL831864 CAD38556 BC002543 BC020166 AAH20166 BC140367 AAI40368 BQ961819 BU539058 XM_005248373 XP_005248430 XM_011514132 XP_011512434 XM_011514133 XP_011512435 XM_011514134 XP_011512436 NM_024830 NP_079106
Function Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. {ECO:0000269|PubMed:16864775, ECO:0000269|PubMed:21498505}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
Top Pathways Ether lipid metabolism, Glycerophospholipid metabolism

LPCAT1 (E-14) - sc-160495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LPCAT1 antibody - ab94903 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab94903 stained A549 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab94903, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-LPCAT1 antibody - ab115458 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115458 at 10 &microg/ml staining Formalin-fixed, Paraffin-embedded LPCAT1 in Human Brain cerebellum tissue by Immunohistochemistry.

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, AP) - LS-C216623 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, APC) - LS-C216624 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, Biotin) - LS-C216625 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, FITC) - LS-C216626 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, Azide-free, HRP) - LS-C216628 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa506-534, PE) - LS-C216630 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa505-534) - LS-C323820 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LPCAT1 / AYTL2 Antibody (aa323-372) - LS-C111241 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LPCAT1 antibody LS-C111241 Western blot of Fetal Small Intestine lysate.

Anti-LPCAT1 / AYTL2 Antibody (C-Terminus) - LS-C345680 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PCAT1 Antibody with human Fetal Lung lysate.

Anti-LPCAT1 / AYTL2 Antibody (aa506-534) - LS-C163405 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human spleen tissue reacted with PCAT1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-LPCAT1 / AYTL2 Antibody (Internal) IHC-plus™ - LS-A9903 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LPCAT1 antibody LS-A9903 IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-LPCAT1 / AYTL2 Antibody (Internal) IHC-plus™ - LS-A9904 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LPCAT1 antibody LS-A9904 IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LPCAT1 Antibody - NBP1-88923 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LPCAT1 Antibody [NBP1-88923] - Analysis in human cell line BEWO.

LPCAT1 Antibody - NBP1-88922 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: LPCAT1 Antibody [NBP1-88922] - Staining of human lung shows strong cytoplasmic positivity in alveolar cells.

LPCAT1 Antibody - NBP1-50174 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: LPCAT1 Antibody [NBP1-50174] - Analysis of anti-LPCAT1 antibody with human thyroid.

ANTI-PCAT1(C-TERMINAL) antibody produced in rabbit - SAB1306544 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PCAT1 (C-term): <B>Cat. No. SAB1306544</B>: Western blot analysis of PCAT1 Antibody (C-term) in HeLa cell line lysates (35 μg/lane).

Anti-LPCAT1 antibody produced in rabbit - HPA012501 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AYTL2: <B>Cat. No. HPA012501</B>: Immunohistochemical staining of human lung shows strong cytoplasmic positivity in alveolar cells.

Anti-LPCAT1 antibody produced in rabbit - SAB2104331 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LPCAT1, antibody produced in rabbit: <B>Cat. No. SAB2104331</B>: Immunoblotting analysis of LPCAT1 in fetal Small intestine with LPCAT1 anitbody at 1 μg/mL.

Anti-LPCAT1 antibody produced in rabbit - HPA022268 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AYTL2: <B>Cat. No. HPA022268</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

LPCAT1 antibody - middle region (ARP49884_P050) - ARP49884_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PCAT1 Antibody - C-terminal region (ARP74038_P050) - ARP74038_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PCAT1-Antibody-C-term - AP9310b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PCAT1 Antibody (C-term) (Cat.#AP9310b) in Hela cell line lysates (35ug/lane). PCAT1 (arrow) was detected using the purified Pab.
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