LPCAT1
| Gene Symbol | LPCAT1 |
|---|---|
| Entrez Gene | 79888 |
| Alt Symbol | AYTL2, PFAAP3, lpcat |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysophosphatidylcholine acyltransferase 1 |
| Other Description | 1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPC acyltransferase 1|LPCAT-1|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 1|acyltransferase like 2|acyltransferase-like 2|lyso-PAF acetyltransferase|lysoPAFAT|lysoPC acyltransferase 1|phosphonoformate immuno-associated protein 3|regulated by phosphonoformate |
| Swissprots | Q8NF37 Q1HAQ1 Q9GZW6 Q7Z4G6 Q8WUL8 Q8N3U7 |
| Accessions | EAX08154 EAX08155 EAX08156 Q8NF37 AB244719 BAE94688 AF052162 AF530061 AAQ09945 AK022499 BAB14061 AK022505 BAB14065 AK090444 BAC03425 AK095552 AK123603 AL831864 CAD38556 BC002543 BC020166 AAH20166 BC140367 AAI40368 BQ961819 BU539058 XM_005248373 XP_005248430 XM_011514132 XP_011512434 XM_011514133 XP_011512435 XM_011514134 XP_011512436 NM_024830 NP_079106 |
| Function | Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. {ECO:0000269|PubMed:16864775, ECO:0000269|PubMed:21498505}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. |
| Top Pathways | Ether lipid metabolism, Glycerophospholipid metabolism |
LPCAT1 CRISPR/Cas9 KO Plasmid (h) - sc-413287 from Santa Cruz Biotechnology
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LPCAT1 HDR Plasmid (h) - sc-413287-HDR from Santa Cruz Biotechnology
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LPCAT1 Double Nickase Plasmid (h) - sc-413287-NIC from Santa Cruz Biotechnology
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LPCAT1 Double Nickase Plasmid (h2) - sc-413287-NIC-2 from Santa Cruz Biotechnology
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LPCAT1 CRISPR Activation Plasmid (h) - sc-413287-ACT from Santa Cruz Biotechnology
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LPCAT1 CRISPR Activation Plasmid (h2) - sc-413287-ACT-2 from Santa Cruz Biotechnology
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LPCAT1 Lentiviral Activation Particles (h) - sc-413287-LAC from Santa Cruz Biotechnology
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LPCAT1 Lentiviral Activation Particles (h2) - sc-413287-LAC-2 from Santa Cruz Biotechnology
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LPCAT1 siRNA (h) - sc-91777 from Santa Cruz Biotechnology
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LPCAT1 shRNA Plasmid (h) - sc-91777-SH from Santa Cruz Biotechnology
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LPCAT1 shRNA (h) Lentiviral Particles - sc-91777-V from Santa Cruz Biotechnology
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LPCAT1 RNAi - H00079888-R01 from Novus Biologicals
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MISSION® esiRNA - EHU130601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12647 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12647 from Sigma-Aldrich
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LPCAT1 siRNA (Human) - CRJ2643 from Cohesion Biosciences
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shRNA set against Human LPCAT1 (NM_024830.3) - SHH333467 from Creative biogene
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shRNA set against Human AYTL2(NM_024830.3) - SHH000379 from Creative biogene
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Human LPCAT1 siRNA - orb273144 from Biorbyt
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LPCAT1 shRNA Plasmid (Human) - CHJ2643 from Cohesion Biosciences
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LPCAT1 miRNA 3'UTR clone - MiUTR1H-00755 from Creative biogene
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