UBR4

Gene Symbol UBR4
Entrez Gene 23352
Alt Symbol RBAF600, ZUBR1, p600
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 4
Other Description E3 ubiquitin-protein ligase UBR4|N-recognin-4|retinoblastoma-associated factor 600-like protein|retinoblastoma-associated factor of 600 kDa|zinc finger UBR1-type protein 1
Swissprots Q5TBP2 Q5T4S9 A8MQB1 A8MPT2 O60646 Q9UG82 Q9P2N9 Q6DKH8 Q9HA46 A8MQ33 Q8IXJ4 Q5T4S8 Q6P4A4 Q8TDN5 Q4QRK5 Q5T4S7 O75050 Q8WV67 Q7L8P7 Q5TBN8
Accessions CCO13845 EAW94864 EAW94865 EAW94866 EAW94867 EAW94868 EAW94869 Q5T4S7 AA748129 AB007931 BAA32307 AB037728 BAA92545 AF055010 AAC09360 AF348492 AAL83880 AJ505016 CAD43719 AK000331 AK001233 BAG50874 AK022322 BAB14011 AK022573 BAG51094 AK022924 AK023826 AK024105 AK025149 AK026543 AK056218 AK092390 AK123857 AK125800 BAC86298 AK298314 BAG60568 AK302623 BAG63867 AL049972 CAB43227 BC007962 AAH07962 BC015865 BC018694 AAH18694 BC041137 BC063573 AAH63573 BC073905 AAH73905 BC096758 AAH96758 XM_011541108 XP_011539410 XM_011541109 XP_011539411 XM_011541110 XP_011539412 XM_011541111 XP_011539413 XM_011541112 XP_011539414 XM_011541113 XP_011539415 XM_011541114 XP_011539416 XM_011541115 XP_011539417 XM_011541116 XP_011539418 XM_011541117 XP_011539419 XM_011541118 XP_011539420 XM_011541119 XP_011539421 XM_011541120 XP_011539422 XM_011541121 XP_011539423 XR_946593 XR_946594 NM_020765 NP_065816
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Top Pathways Viral carcinogenesis

Ubr4 (E-14) - sc-162376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ubr4 (21-Y) - sc-100615 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Ubr4 (21-Y): sc-100615. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

Anti-UBR4 antibody - ab86738 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling UBR4 with ab86738 at 1/200 (1µg/ml). Detection: DAB.

Anti-UBR4 antibody - ab187879 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded Human spleen tissue labeling UBR4 with ab187879 at 5μg/ml dilution.

Anti-UBR4 antibody - ab114109 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling UBR4 with ab114109 at 1/1000 (1µg/ml). Detection: DAB.

Anti-UBR4 antibody - ab57045 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-UBR4 Antibody (aa94-191, Azide-free) - LS-C328487 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-UBR4 Antibody (aa150-200) - LS-C286106 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human p600 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p600 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-UBR4 Antibody (aa1350-1400) - LS-C289030 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human p600 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p600 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-UBR4 Antibody (aa5133-5183) - LS-C289031 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human p600 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p600 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-UBR4 Antibody (aa5133-5183) - LS-C286846 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human p600 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p600 used at a dilution of 1:100. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated (A120-601D4) used at a dilution of 1:100.

Anti-UBR4 Antibody (aa5002-5015) IHC-plus™ - LS-B9504 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UBR4 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

UBR4 Antibody - NBP1-28730 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UBR4 Antibody [NBP1-28730] - Detection of Human p600 on HeLa whole cell lysate using NBP28730. p600 was also immunoprecipitated by rabbit anti-p600 antibodies NBP1-28683 and NBP1-28724.

UBR4 Antibody (2D12) - H00023352-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D12
Western Blot: UBR4 Antibody (2D12) [H00023352-M01] - RBAF600 expression in K-562 ( Cat # L009V1 ).

UBR4 Antibody - NBP1-28724 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UBR4 Antibody - NBP1-71952 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: UBR4 Antibody [NBP1-71952]-FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p600 used at a dilution of 1:250.

UBR4 Antibody - NBP1-45235 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: UBR4 Antibody [NBP1-45235] - Staining of Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

UBR4 Antibody - H00023352-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Monoclonal Anti-RBAF600 antibody produced in mouse - WH0023352M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D12
<B>Immunoblotting</B><BR/>Monoclonal Anti-RBAF600, <B>Cat. No. WH0023352M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~66.7 kDa using K-562 lysate.

Anti-UBR4 antibody produced in rabbit - HPA021046 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UBR4: <B>Cat. No. HPA021046</B>: Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.

RBAF600-Antibody-monoclonal-M01 - AT3584a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D12
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.41 KDa) .

UBR4--ZUBR1-Antibody-C-Term - AF3012a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3012a (5 µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

IL-13 antibody [EP3266] - GTX62746 from GeneTex

Host Rabbit
Clonality Monoclonal
Clone EP3266
Anti-IL-13 antibody [EP3266] used in Western blot. GTX62746

IL-13 antibody [EPR3267] - GTX62749 from GeneTex

Host Rabbit
Clonality Monoclonal
Clone EPR3267
Anti-IL-13 antibody [EPR3267] used in Western blot. GTX62749

Goat Anti-UBR4 / ZUBR1 Antibody (OAEB00075) - OAEB00075 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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