UBR4

Gene Symbol	UBR4
Entrez Gene	23352
Alt Symbol	RBAF600, ZUBR1, p600
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 4
Other Description	E3 ubiquitin-protein ligase UBR4|N-recognin-4|retinoblastoma-associated factor 600-like protein|retinoblastoma-associated factor of 600 kDa|zinc finger UBR1-type protein 1
Swissprots	Q5TBP2 Q5T4S9 A8MQB1 A8MPT2 O60646 Q9UG82 Q9P2N9 Q6DKH8 Q9HA46 A8MQ33 Q8IXJ4 Q5T4S8 Q6P4A4 Q8TDN5 Q4QRK5 Q5T4S7 O75050 Q8WV67 Q7L8P7 Q5TBN8
Accessions	CCO13845 EAW94864 EAW94865 EAW94866 EAW94867 EAW94868 EAW94869 Q5T4S7 AA748129 AB007931 BAA32307 AB037728 BAA92545 AF055010 AAC09360 AF348492 AAL83880 AJ505016 CAD43719 AK000331 AK001233 BAG50874 AK022322 BAB14011 AK022573 BAG51094 AK022924 AK023826 AK024105 AK025149 AK026543 AK056218 AK092390 AK123857 AK125800 BAC86298 AK298314 BAG60568 AK302623 BAG63867 AL049972 CAB43227 BC007962 AAH07962 BC015865 BC018694 AAH18694 BC041137 BC063573 AAH63573 BC073905 AAH73905 BC096758 AAH96758 XM_011541108 XP_011539410 XM_011541109 XP_011539411 XM_011541110 XP_011539412 XM_011541111 XP_011539413 XM_011541112 XP_011539414 XM_011541113 XP_011539415 XM_011541114 XP_011539416 XM_011541115 XP_011539417 XM_011541116 XP_011539418 XM_011541117 XP_011539419 XM_011541118 XP_011539420 XM_011541119 XP_011539421 XM_011541120 XP_011539422 XM_011541121 XP_011539423 XR_946593 XR_946594 NM_020765 NP_065816
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Top Pathways	Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBR4 protein fragment - ab153218 from Abcam Category Protein Source Wheat germ Species Human

UBR4 Antibody Blocking Peptide - LS-E27164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBR4 Protein - H00023352-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL13 recombinant protein - GTX65146 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Human

UBR4 blocking peptide - GTX88365-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

UBR4 Peptide - AC21-1984-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBR4 - H00023352-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBR4 - H00023352-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBR4 Peptide - 42-191P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

UBR4 fusion protein - Ag9099 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

UBR4 fusion protein - Ag8740 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human UBR4, His-tagged - UBR4-3562H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) - RPL074Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) - RPL074Hu01 from Cloud-clone Category Protein Source E.coli Species Human

UBR4 Protein (Recombinant) - abx165885 from Abbexa Category Protein Source Human Species Human

UBR4/ZUBR1, Peptide - MBS425338 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

UBR4 Recombinant Protein Antigen - NBP1-83003PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UBR4 Peptide, Human - M34GP17006H from Creative Peptides Category Peptide Source Synthetic. Species Human

UBR4 Recombinant Protein (OPCD07797) - OPCD07797 from Aviva Systems Biology Category Protein Source E.coli Species Human

UBR4 Immunizing peptide - orb59553 from Biorbyt Category Peptide

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