| Gene Symbol |
UBR4
|
| Entrez Gene |
23352
|
| Alt Symbol |
RBAF600, ZUBR1, p600
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin protein ligase E3 component n-recognin 4
|
| Other Description |
E3 ubiquitin-protein ligase UBR4|N-recognin-4|retinoblastoma-associated factor 600-like protein|retinoblastoma-associated factor of 600 kDa|zinc finger UBR1-type protein 1
|
| Swissprots |
Q5TBP2 Q5T4S9 A8MQB1 A8MPT2 O60646 Q9UG82 Q9P2N9 Q6DKH8 Q9HA46 A8MQ33 Q8IXJ4 Q5T4S8 Q6P4A4 Q8TDN5 Q4QRK5 Q5T4S7 O75050 Q8WV67 Q7L8P7 Q5TBN8
|
| Accessions |
CCO13845 EAW94864 EAW94865 EAW94866 EAW94867 EAW94868 EAW94869 Q5T4S7 AA748129 AB007931 BAA32307 AB037728 BAA92545 AF055010 AAC09360 AF348492 AAL83880 AJ505016 CAD43719 AK000331 AK001233 BAG50874 AK022322 BAB14011 AK022573 BAG51094 AK022924 AK023826 AK024105 AK025149 AK026543 AK056218 AK092390 AK123857 AK125800 BAC86298 AK298314 BAG60568 AK302623 BAG63867 AL049972 CAB43227 BC007962 AAH07962 BC015865 BC018694 AAH18694 BC041137 BC063573 AAH63573 BC073905 AAH73905 BC096758 AAH96758 XM_011541108 XP_011539410 XM_011541109 XP_011539411 XM_011541110 XP_011539412 XM_011541111 XP_011539413 XM_011541112 XP_011539414 XM_011541113 XP_011539415 XM_011541114 XP_011539416 XM_011541115 XP_011539417 XM_011541116 XP_011539418 XM_011541117 XP_011539419 XM_011541118 XP_011539420 XM_011541119 XP_011539421 XM_011541120 XP_011539422 XM_011541121 XP_011539423 XR_946593 XR_946594 NM_020765 NP_065816
|
| Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
|
| Top Pathways |
Viral carcinogenesis
|