UBR4

Gene Symbol	UBR4
Entrez Gene	23352
Alt Symbol	RBAF600, ZUBR1, p600
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 4
Other Description	E3 ubiquitin-protein ligase UBR4|N-recognin-4|retinoblastoma-associated factor 600-like protein|retinoblastoma-associated factor of 600 kDa|zinc finger UBR1-type protein 1
Swissprots	Q5TBP2 Q5T4S9 A8MQB1 A8MPT2 O60646 Q9UG82 Q9P2N9 Q6DKH8 Q9HA46 A8MQ33 Q8IXJ4 Q5T4S8 Q6P4A4 Q8TDN5 Q4QRK5 Q5T4S7 O75050 Q8WV67 Q7L8P7 Q5TBN8
Accessions	CCO13845 EAW94864 EAW94865 EAW94866 EAW94867 EAW94868 EAW94869 Q5T4S7 AA748129 AB007931 BAA32307 AB037728 BAA92545 AF055010 AAC09360 AF348492 AAL83880 AJ505016 CAD43719 AK000331 AK001233 BAG50874 AK022322 BAB14011 AK022573 BAG51094 AK022924 AK023826 AK024105 AK025149 AK026543 AK056218 AK092390 AK123857 AK125800 BAC86298 AK298314 BAG60568 AK302623 BAG63867 AL049972 CAB43227 BC007962 AAH07962 BC015865 BC018694 AAH18694 BC041137 BC063573 AAH63573 BC073905 AAH73905 BC096758 AAH96758 XM_011541108 XP_011539410 XM_011541109 XP_011539411 XM_011541110 XP_011539412 XM_011541111 XP_011539413 XM_011541112 XP_011539414 XM_011541113 XP_011539415 XM_011541114 XP_011539416 XM_011541115 XP_011539417 XM_011541116 XP_011539418 XM_011541117 XP_011539419 XM_011541118 XP_011539420 XM_011541119 XP_011539421 XM_011541120 XP_011539422 XM_011541121 XP_011539423 XR_946593 XR_946594 NM_020765 NP_065816
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Top Pathways	Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ubr4 CRISPR/Cas9 KO Plasmid (h) - sc-408481 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 HDR Plasmid (h) - sc-408481-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 Double Nickase Plasmid (h) - sc-408481-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 Double Nickase Plasmid (h2) - sc-408481-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 CRISPR Activation Plasmid (h) - sc-408481-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 CRISPR Activation Plasmid (h2) - sc-408481-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 Lentiviral Activation Particles (h) - sc-408481-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 Lentiviral Activation Particles (h2) - sc-408481-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ubr4 siRNA (h) - sc-78618 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ubr4 shRNA Plasmid (h) - sc-78618-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ubr4 shRNA (h) Lentiviral Particles - sc-78618-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBR4 RNAi - H00023352-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU044461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22417 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22417 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02559 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02559

UBR4 siRNA (Human) - CRH8202 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBR4 - MBS829330 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UBR4 (NM_020765.2) - SHH439552 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ZUBR1(NM_020765.2) - SHL103824 from Creative biogene Category siRNA Species Reactivities Human

Human UBR4 siRNA - orb268704 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBR4 shRNA Plasmid (Human) - CHH8202 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBR4 miRNA 3'UTR clone - MiUTR1H-11770 from Creative biogene Species Reactivities Human

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