UBR4

Gene Symbol	UBR4
Entrez Gene	23352
Alt Symbol	RBAF600, ZUBR1, p600
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 4
Other Description	E3 ubiquitin-protein ligase UBR4|N-recognin-4|retinoblastoma-associated factor 600-like protein|retinoblastoma-associated factor of 600 kDa|zinc finger UBR1-type protein 1
Swissprots	Q5TBP2 Q5T4S9 A8MQB1 A8MPT2 O60646 Q9UG82 Q9P2N9 Q6DKH8 Q9HA46 A8MQ33 Q8IXJ4 Q5T4S8 Q6P4A4 Q8TDN5 Q4QRK5 Q5T4S7 O75050 Q8WV67 Q7L8P7 Q5TBN8
Accessions	CCO13845 EAW94864 EAW94865 EAW94866 EAW94867 EAW94868 EAW94869 Q5T4S7 AA748129 AB007931 BAA32307 AB037728 BAA92545 AF055010 AAC09360 AF348492 AAL83880 AJ505016 CAD43719 AK000331 AK001233 BAG50874 AK022322 BAB14011 AK022573 BAG51094 AK022924 AK023826 AK024105 AK025149 AK026543 AK056218 AK092390 AK123857 AK125800 BAC86298 AK298314 BAG60568 AK302623 BAG63867 AL049972 CAB43227 BC007962 AAH07962 BC015865 BC018694 AAH18694 BC041137 BC063573 AAH63573 BC073905 AAH73905 BC096758 AAH96758 XM_011541108 XP_011539410 XM_011541109 XP_011539411 XM_011541110 XP_011539412 XM_011541111 XP_011539413 XM_011541112 XP_011539414 XM_011541113 XP_011539415 XM_011541114 XP_011539416 XM_011541115 XP_011539417 XM_011541116 XP_011539418 XM_011541117 XP_011539419 XM_011541118 XP_011539420 XM_011541119 XP_011539421 XM_011541120 XP_011539422 XM_011541121 XP_011539423 XR_946593 XR_946594 NM_020765 NP_065816
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.
Top Pathways	Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBR4 ELISA Kit (Sandwich ELISA) - LS-F8442 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.064 ng/ml Range 0.156-10 ng/ml

Human UBR4 ELISA Kit (Competitive EIA) - LS-F12896 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.156-10 ng/ml

E3 ubiquitin-protein ligase UBR4, UBR4, Human, ELISA Kit - E0192h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4), Human, ELISA Kit - SEL074Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Human, ELISA Kit - E-EL-H2378 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Rabbit, ELISA Kit - E-EL-RB0382 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Chicken, ELISA Kit - E-EL-Ch0381 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Porcine, ELISA Kit - E-EL-P1656 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Sheep, ELISA Kit - E-EL-S0773 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Ubiquitin Protein Ligase E3 Component N-Recognin 4, UBR4, Monkey, ELISA Kit - E-EL-MK0896 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human UBR4(Ubiquitin Protein Ligase E3 Component N-Recognin 4) ELISA Kit - E-EL-H2378 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) CLIA Kit - E-CL-H1383 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

ubiquitin protein ligase E3 component n-recognin 4, ELISA Kit - MBS9328287 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UBR4, ELISA Kit - MBS2505330 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

ELISA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) - SEL074Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.064ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) - SEL074Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.064ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat UBR4 ELISA Kit (Custom ELISA) - LS-F13955 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse UBR4 ELISA Kit (Custom ELISA) - LS-F13956 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human UBR4(Ubiquitin Protein Ligase E3 Component N-Recognin 4) ELISA Kit - E-EL-H2378 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human UBR4 ELISA Kit - abx153427 from Abbexa Category ELISA Kit Sensitivity 0.064 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human UBR4 ELISA Kit (Sandwich ELISA) - LS-F21252 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4), Human, ELISA Kit - DL-UBR4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

UBR4 - EKH1516 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

UBR4 ELISA Kit (Human) : 96 Wells (OKEH00289) - OKEH00289 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.22 ng/mL Range 0.625 - 40 ng/mL

Human UBR4 ELISA Kit - E012657 from Biobool Category ELISA Kit

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