| Gene Symbol | CITED1 |
|---|---|
| Entrez Gene | 4435 |
| Alt Symbol | MSG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
| Other Description | cbp/p300-interacting transactivator 1|melanocyte-specific gene 1|melanocyte-specific protein 1 |
| Swissprots | B5BUI2 B5BU50 Q99966 |
| Accessions | EAW71818 EAW71819 EAW71820 Q99966 AB451286 BAG70100 AB451418 BAG70232 AI217516 BC004240 AAH04240 BP247232 DQ892984 ABM83910 DQ896232 ABM87231 N27803 U65092 AAC51113 XM_011530958 XP_011529260 NM_001144885 NP_001138357 NM_001144886 NP_001138358 NM_001144887 NP_001138359 NM_004143 NP_004134 |
| Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16864582}. Cytoplasm {ECO:0000269|PubMed:16864582}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner. |
| Tissue Specificity | Expressed only in melanocytes and testis. |
Human CITED1 cDNA clone(NM_001144886.1) - CDFH003716 from Creative Biomart
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Human CITED1 cDNA clone(NM_001144885.1) - CDFH003717 from Creative Biomart
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Human CITED1 cDNA clone(NM_001144887.1) - CDFH003718 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144885.1) - CDCR352092 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144886.1) - CDCR352093 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144886.1) - CDCR352094 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144887.1) - CDCR352095 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144885.1) - CDCR352096 from Creative Biomart
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Human CITED1 ORF Clone(NM_001144887.1) - CDCR352097 from Creative Biomart
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Human CITED1 ORF clone(NM_004143.3) - CDCH383241 from Creative Biomart
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Human CITED1 ORF Clone(NM_004143.3) - CDCL158910 from Creative Biomart
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Human CITED1 ORF clone(NM_004143.3) - CDCH383241 from Creative biogene
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Human CITED1 ORF Clone(NM_001144887.1) - CDCR352095 from Creative biogene
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Human CITED1 ORF clone (NM_001144886.1) - CDCR042006 from Creative biogene
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Human CITED1 ORF clone (NM_001144885.1) - CDCR042008 from Creative biogene
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Human CITED1 cDNA Clone(NM_001144886.1) - CDFH003716 from Creative biogene
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Human CITED1 cDNA Clone(NM_001144885.1) - CDFH003717 from Creative biogene
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Human CITED1 cDNA Clone(NM_001144887.1) - CDFH003718 from Creative biogene
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