Gene Symbol | CITED1 |
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Entrez Gene | 4435 |
Alt Symbol | MSG1 |
Species | Human |
Gene Type | protein-coding |
Description | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
Other Description | cbp/p300-interacting transactivator 1|melanocyte-specific gene 1|melanocyte-specific protein 1 |
Swissprots | B5BUI2 B5BU50 Q99966 |
Accessions | EAW71818 EAW71819 EAW71820 Q99966 AB451286 BAG70100 AB451418 BAG70232 AI217516 BC004240 AAH04240 BP247232 DQ892984 ABM83910 DQ896232 ABM87231 N27803 U65092 AAC51113 XM_011530958 XP_011529260 NM_001144885 NP_001138357 NM_001144886 NP_001138358 NM_001144887 NP_001138359 NM_004143 NP_004134 |
Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16864582}. Cytoplasm {ECO:0000269|PubMed:16864582}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner. |
Tissue Specificity | Expressed only in melanocytes and testis. |
MSG1 CRISPR/Cas9 KO Plasmid (h) - sc-404984 from Santa Cruz Biotechnology
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MSG1 HDR Plasmid (h) - sc-404984-HDR from Santa Cruz Biotechnology
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MSG1 Double Nickase Plasmid (h) - sc-404984-NIC from Santa Cruz Biotechnology
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MSG1 Double Nickase Plasmid (h2) - sc-404984-NIC-2 from Santa Cruz Biotechnology
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MSG1 CRISPR Activation Plasmid (h) - sc-404984-ACT from Santa Cruz Biotechnology
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MSG1 CRISPR Activation Plasmid (h2) - sc-404984-ACT-2 from Santa Cruz Biotechnology
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MSG1 Lentiviral Activation Particles (h) - sc-404984-LAC from Santa Cruz Biotechnology
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MSG1 Lentiviral Activation Particles (h2) - sc-404984-LAC-2 from Santa Cruz Biotechnology
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MSG1 siRNA (h) - sc-38049 from Santa Cruz Biotechnology
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MSG1 shRNA Plasmid (h) - sc-38049-SH from Santa Cruz Biotechnology
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MSG1 shRNA (h) Lentiviral Particles - sc-38049-V from Santa Cruz Biotechnology
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CITED1 RNAi - H00004435-R01V from Novus Biologicals
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CITED1 RNAi - H00004435-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6144 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6144 from Sigma-Aldrich
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CITED1 siRNA (Human) - CRH2967 from Cohesion Biosciences
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CITED1 - MBS8200558 from MyBioSource
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shRNA set against Human CITED1 (NM_004143.3) - SHH264241 from Creative biogene
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CITED1 shRNA Plasmid (Human) - CHH2967 from Cohesion Biosciences
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CITED1 miRNA 3'UTR clone - MiUTR4H-TG10900 from Creative biogene
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