| Gene Symbol |
MED21
|
| Entrez Gene |
9412
|
| Alt Symbol |
SRB7, SURB7, hSrb7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 21
|
| Other Description |
RNA polymerase II holoenzyme component SRB7|RNAPII complex component SRB7|SRB7 suppressor of RNA polymerase B homolog|mediator of RNA polymerase II transcription subunit 21
|
| Swissprots |
Q92811 Q6IB05 Q13503 B2R4I3
|
| Accessions |
EAW96544 EAW96545 EAW96546 EAW96547 Q13503 AK309064 AK311838 BAG34780 BC008380 AAH08380 CR456999 CAG33280 DA420057 DB024509 EU446930 ABZ92459 HY075642 U46837 AAA98511 U52960 AAB06944 NM_001271811 NP_001258740 NM_004264 NP_004255 NR_073463 NR_073464
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15249124, ECO:0000269|PubMed:9660976}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: MED21 Overexpression Lysate (Adult Normal) [NBL1-12986] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MED21.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9534_MED21%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12986-img0002.jpg)