Gene Symbol | MED21 |
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Entrez Gene | 9412 |
Alt Symbol | SRB7, SURB7, hSrb7 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 21 |
Other Description | RNA polymerase II holoenzyme component SRB7|RNAPII complex component SRB7|SRB7 suppressor of RNA polymerase B homolog|mediator of RNA polymerase II transcription subunit 21 |
Swissprots | Q92811 Q6IB05 Q13503 B2R4I3 |
Accessions | EAW96544 EAW96545 EAW96546 EAW96547 Q13503 AK309064 AK311838 BAG34780 BC008380 AAH08380 CR456999 CAG33280 DA420057 DB024509 EU446930 ABZ92459 HY075642 U46837 AAA98511 U52960 AAB06944 NM_001271811 NP_001258740 NM_004264 NP_004255 NR_073463 NR_073464 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15249124, ECO:0000269|PubMed:9660976}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Human Surb7 full length protein - ab156980 from Abcam
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Human Surb7 full length protein - ab160479 from Abcam
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MED21 Antibody Blocking Peptide - LS-E12697 from LifeSpan Bioscience
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MED21 Antibody Blocking Peptide - LS-E12698 from LifeSpan Bioscience
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MED21 Antibody Blocking Peptide - LS-E13532 from LifeSpan Bioscience
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MED21 Recombinant Protein - H00009412-P01 from Novus Biologicals
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Recombinant Human MED21 Protein - NBP2-23221 from Novus Biologicals
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Human MED21 protein - orb191160 from Biorbyt
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MED21 protein (His tag) - 80R-2823 from Fitzgerald
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MED21 (1-144, His-tag) - AR50942PU-N from Acris Antibodies
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MED21 (1-144, His-tag) - AR50942PU-S from Acris Antibodies
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MED21 - H00009412-P01-10 from Acris Antibodies
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MED21 - H00009412-P01-25 from Acris Antibodies
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MED21, 1-144aa, Human, His tag, E.coli - 01-P2118 from ARP American Research Products
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MED21 fusion protein - Ag8639 from Proteintech Group
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MED21 fusion protein - ag8568 from Proteintech Group
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Recombinant Human MED21, His-tagged - MED21-7607H from Creative Biomart
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Recombinant Human MED21, GST-tagged - MED21-807H from Creative Biomart
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Recombinant Mediator of RNA polymerase II transcription subunit 21(mdt-21) - CSB-YP726768CXX CSB-EP726768CXX CSB-BP726768CXX CSB-MP726768CXX from Cusabio
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Recombinant Human Mediator of RNA polymerase II transcription subunit 21(MED21) - CSB-YP619773HU CSB-EP619773HU CSB-BP619773HU CSB-MP619773HU from Cusabio
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MED21, 1-144aa, Human, His tag, E.coli - ATGP2118 from ATGen
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Mediator Complex Subunit 21 Protein (Recombinant) - abx262618 from Abbexa
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MED21 - TP302763 from Acris Antibodies
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MED21 Recombinant Protein Antigen - NBP1-87006PEP from Novus Biologicals
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MED21 Peptide, Human - M34GP09366H from Creative Peptides
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