Gene Symbol | MED21 |
---|---|
Entrez Gene | 9412 |
Alt Symbol | SRB7, SURB7, hSrb7 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 21 |
Other Description | RNA polymerase II holoenzyme component SRB7|RNAPII complex component SRB7|SRB7 suppressor of RNA polymerase B homolog|mediator of RNA polymerase II transcription subunit 21 |
Swissprots | Q92811 Q6IB05 Q13503 B2R4I3 |
Accessions | EAW96544 EAW96545 EAW96546 EAW96547 Q13503 AK309064 AK311838 BAG34780 BC008380 AAH08380 CR456999 CAG33280 DA420057 DB024509 EU446930 ABZ92459 HY075642 U46837 AAA98511 U52960 AAB06944 NM_001271811 NP_001258740 NM_004264 NP_004255 NR_073463 NR_073464 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15249124, ECO:0000269|PubMed:9660976}. |
Subcellular Location | Nucleus {ECO:0000305}. |