| Gene Symbol |
WWP1
|
| Entrez Gene |
11059
|
| Alt Symbol |
AIP5, Tiul1, hSDRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WW domain containing E3 ubiquitin protein ligase 1
|
| Other Description |
NEDD4-like E3 ubiquitin-protein ligase WWP1|Nedd-4-like ubiquitin-protein ligase|TGIF-interacting ubiquitin ligase 1|WW domain-containing protein 1|atrophin-1 interacting protein 5|atrophin-1-interacting protein 5
|
| Swissprots |
O00307 Q5YLC1 Q96BP4 Q9H0M0
|
| Accessions |
EAW91634 EAW91635 EAW91636 EAW91637 Q9H0M0 AK292800 BAF85489 AK310683 AL050082 AL136739 CAB66673 AW137654 AY043361 AAK94668 AY345857 AAQ22764 BC015380 AAH15380 BC036065 AAH36065 BM664090 EU832274 ACE87531 EU832359 ACE86844 U96113 AAC51324 XM_005250760 XP_005250817 XM_005250761 XP_005250818 XM_011516802 XP_011515104 NM_007013 NP_008944
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269|PubMed:11779188, ECO:0000269|PubMed:9647693}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Endocytosis
|