WWP1

Gene Symbol WWP1
Entrez Gene 11059
Alt Symbol AIP5, Tiul1, hSDRP1
Species Human
Gene Type protein-coding
Description WW domain containing E3 ubiquitin protein ligase 1
Other Description NEDD4-like E3 ubiquitin-protein ligase WWP1|Nedd-4-like ubiquitin-protein ligase|TGIF-interacting ubiquitin ligase 1|WW domain-containing protein 1|atrophin-1 interacting protein 5|atrophin-1-interacting protein 5
Swissprots O00307 Q5YLC1 Q96BP4 Q9H0M0
Accessions EAW91634 EAW91635 EAW91636 EAW91637 Q9H0M0 AK292800 BAF85489 AK310683 AL050082 AL136739 CAB66673 AW137654 AY043361 AAK94668 AY345857 AAQ22764 BC015380 AAH15380 BC036065 AAH36065 BM664090 EU832274 ACE87531 EU832359 ACE86844 U96113 AAC51324 XM_005250760 XP_005250817 XM_005250761 XP_005250818 XM_011516802 XP_011515104 NM_007013 NP_008944
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269|PubMed:11779188, ECO:0000269|PubMed:9647693}.
Top Pathways Ubiquitin mediated proteolysis, Endocytosis

AIP5 CRISPR/Cas9 KO Plasmid (h) - sc-403772 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 HDR Plasmid (h) - sc-403772-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 Double Nickase Plasmid (h) - sc-403772-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 Double Nickase Plasmid (h2) - sc-403772-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 CRISPR Activation Plasmid (h) - sc-403772-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 CRISPR Activation Plasmid (h2) - sc-403772-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 Lentiviral Activation Particles (h) - sc-403772-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 Lentiviral Activation Particles (h2) - sc-403772-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AIP5 siRNA (h) - sc-40366 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AIP5 shRNA Plasmid (h) - sc-40366-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AIP5 shRNA (h) Lentiviral Particles - sc-40366-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WWP1 RNAi - H00011059-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU116771 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU111351 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22943 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22943 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

WWP1 siRNA (Human) - CRH7557 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WWP1 - MBS8225767 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human WWP1(NM_007013.3) - SHL137214 from Creative biogene

Category siRNA
Species Reactivities Human

Human WWP1 siRNA - orb268059 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

WWP1 shRNA Plasmid (Human) - CHH7557 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

WWP1 miRNA 3'UTR clone - MiUTR1H-11297 from Creative biogene

Species Reactivities Human
Search more