WWP1

Gene Symbol	WWP1
Entrez Gene	11059
Alt Symbol	AIP5, Tiul1, hSDRP1
Species	Human
Gene Type	protein-coding
Description	WW domain containing E3 ubiquitin protein ligase 1
Other Description	NEDD4-like E3 ubiquitin-protein ligase WWP1|Nedd-4-like ubiquitin-protein ligase|TGIF-interacting ubiquitin ligase 1|WW domain-containing protein 1|atrophin-1 interacting protein 5|atrophin-1-interacting protein 5
Swissprots	O00307 Q5YLC1 Q96BP4 Q9H0M0
Accessions	EAW91634 EAW91635 EAW91636 EAW91637 Q9H0M0 AK292800 BAF85489 AK310683 AL050082 AL136739 CAB66673 AW137654 AY043361 AAK94668 AY345857 AAQ22764 BC015380 AAH15380 BC036065 AAH36065 BM664090 EU832274 ACE87531 EU832359 ACE86844 U96113 AAC51324 XM_005250760 XP_005250817 XM_005250761 XP_005250818 XM_011516802 XP_011515104 NM_007013 NP_008944
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269|PubMed:11779188, ECO:0000269|PubMed:9647693}.
Top Pathways	Ubiquitin mediated proteolysis, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WWP1 full length protein - ab182822 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human WWP1 full length protein - ab95931 from Abcam Category Protein Source Baculovirus Species Human

Human WWP1 peptide - ab43790 from Abcam Category Peptide

Human WWP1 protein fragment - ab161271 from Abcam Category Protein Source Wheat germ Species Human

WWP1 Antibody Blocking Peptide - LS-E15858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WWP1 Protein - H00011059-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WWP1-Antibody-Center-Blocking-peptide - BP10210c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WWP1 Blocking Peptide - 33R-1550 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWP1 - H00011059-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WWP1 - H00011059-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

WWP1 fusion protein - ag13385 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WWP1 fusion protein - ag3582 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WWP1, Active Human Recombinant Protein - GWB-64C08F from Genway Biotech Category Protein Prices $485.00 Sizes 20 µg Species Human

Recombinant Human WWP1, GST-tagged - WWP1-477H from Creative Biomart Category Protein Source Sf9 .

Recombinant Human WWP1, FLAG-tagged - WWP1-31531TH from Creative Biomart Category Protein Source Baculovirus Species Human

Recombinant Human WWP1, GST-tagged - WWP1-75H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP1(WWP1) ,partial - CSB-YP872425HU CSB-EP872425HU CSB-BP872425HU CSB-MP872425HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WWP1 (N-terminus) - WX3935 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

WWP1 Recombinant Protein Antigen - NBP1-89179PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

WWP1 Peptide, Human - M34GP17547H from Creative Peptides Category Peptide Source Synthetic. Species Human

NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1), partial, Recombinant Protein - MBS1287163 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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