WWP1

Gene Symbol	WWP1
Entrez Gene	11059
Alt Symbol	AIP5, Tiul1, hSDRP1
Species	Human
Gene Type	protein-coding
Description	WW domain containing E3 ubiquitin protein ligase 1
Other Description	NEDD4-like E3 ubiquitin-protein ligase WWP1|Nedd-4-like ubiquitin-protein ligase|TGIF-interacting ubiquitin ligase 1|WW domain-containing protein 1|atrophin-1 interacting protein 5|atrophin-1-interacting protein 5
Swissprots	O00307 Q5YLC1 Q96BP4 Q9H0M0
Accessions	EAW91634 EAW91635 EAW91636 EAW91637 Q9H0M0 AK292800 BAF85489 AK310683 AL050082 AL136739 CAB66673 AW137654 AY043361 AAK94668 AY345857 AAQ22764 BC015380 AAH15380 BC036065 AAH36065 BM664090 EU832274 ACE87531 EU832359 ACE86844 U96113 AAC51324 XM_005250760 XP_005250817 XM_005250761 XP_005250818 XM_011516802 XP_011515104 NM_007013 NP_008944
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269|PubMed:11779188, ECO:0000269|PubMed:9647693}.
Top Pathways	Ubiquitin mediated proteolysis, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WWP1 - MBS1267912 from MyBioSource Species Human Accession BC036065

Human WWP1 cDNA clone(NM_007013.3) - CDFH021325 from Creative Biomart Species Human Accession NM_007013.3

Human WWP1 ORF clone(NM_007013.3) - CDCL186782 from Creative Biomart Species Human Accession NM_007013.3

Human WWP1 ORF Clone(NM_007013.3) - CDCR294194 from Creative Biomart Species Human Accession NM_007013.3

Human WWP1 ORF Clone(NM_007013.3) - CDCR294195 from Creative Biomart Species Human Accession NM_007013.3

Human WWP1 ORF Clone(NM_007013.3) - CDCR294196 from Creative Biomart Species Human Accession NM_007013.3

human WWP1 ORF clone - CDCH101622 from Creative Biomart Species Human Accession NM_007013

human WWP1 ORF clone - CDCH101623 from Creative Biomart Species Human Accession NM_007013

Human WWP1 Gene cDNA clone plasmid - HG11471-M from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11471-ACR from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid - HG11471-UT from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11471-CY from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11471-NY from Sino Biological Species Human

Human WWP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11471-M-N from Sino Biological Species Human Accession NM_007013.3

Human WWP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11471-ACG from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11471-NF from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11471-CH from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11471-NH from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11471-NM from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11471-CF from Sino Biological Species Human

Human WWP1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11471-CM from Sino Biological Species Human

Human WWP1 ORF clone(NM_007013.3) - CDCL186782 from Creative biogene Species Human

Human WWP1 ORF Clone (BC036065) - CDCS413029 from Creative biogene Species Human Accession Q9H0M0

Human WWP1 cDNA Clone(NM_007013.3) - CDFH021325 from Creative biogene Species Human

Human WWP1 (NP_008944) VersaClone cDNA - RDC1702 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

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