Gene Symbol | TRAIP |
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Entrez Gene | 10293 |
Alt Symbol | RNF206, TRIP |
Species | Human |
Gene Type | protein-coding |
Description | TRAF interacting protein |
Other Description | E3 ubiquitin-protein ligase TRAIP|TRAF-interacting protein|ring finger protein 206 |
Swissprots | O00467 B5BU84 Q9BWF2 B5BUL3 |
Accessions | EAW65025 EAW65026 Q9BWF2 AB451320 BAG70134 AB451449 BAG70263 AK225873 AK292172 BAF84861 AK295780 BAG58603 BC000310 AAH00310 BC019283 AAH19283 BQ446539 BX473682 EF036504 ABO65090 HQ448174 ADQ32655 U77845 AAB52993 XM_011533264 XP_011531566 XR_940361 NM_005879 NP_005870 |
Function | Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity. {ECO:0000250, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286}. |
Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta. |
TRIP (D-15) - sc-99695 from Santa Cruz Biotechnology
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TRIP (N-12) - sc-99697 from Santa Cruz Biotechnology
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Anti-TRIP antibody - ab4533 from Abcam
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Anti-TRIP antibody - ab151307 from Abcam
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Anti-TRIP antibody - ab80170 from Abcam
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Anti-TRIP antibody [2D4] - ab128109 from Abcam
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Anti-TRAIP / TRIP Antibody (aa67-313, clone 2D4) - LS-C336915 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody - LS-C332519 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (aa328-356) IHC-plus⢠- LS-B7778 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (clone 3E1) - LS-C175121 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (clone 1G3) - LS-C174601 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (clone 1G9) - LS-C174602 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (clone 3A4) - LS-C174598 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (aa457-469) - LS-C55630 from LifeSpan Bioscience
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Anti-TRAIP / TRIP Antibody (aa294-313) - LS-C148304 from LifeSpan Bioscience
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TRAIP Antibody (2D4) - NBP2-03822 from Novus Biologicals
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TRAIP Antibody - NB100-56180 from Novus Biologicals
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TRAIP Antibody - NBP1-87125 from Novus Biologicals
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TRAIP Antibody - NB100-1230 from Novus Biologicals
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TRAIP Antibody - NBP1-31854 from Novus Biologicals
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TRAIP Antibody (2E7) - H00010293-M01 from Novus Biologicals
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TRAIP Antibody - H00010293-A01 from Novus Biologicals
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TRIP Polyclonal Antibody - bs-4603R from Bioss
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Monoclonal Anti-TRAIP, (C-terminal) antibody produced in mouse - SAB1403058 from Sigma-Aldrich
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Anti-TRAIP (C-term) antibody produced in rabbit - SAB1300706 from Sigma-Aldrich
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