| Gene Symbol |
TRAIP
|
| Entrez Gene |
10293
|
| Alt Symbol |
RNF206, TRIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRAF interacting protein
|
| Other Description |
E3 ubiquitin-protein ligase TRAIP|TRAF-interacting protein|ring finger protein 206
|
| Swissprots |
O00467 B5BU84 Q9BWF2 B5BUL3
|
| Accessions |
EAW65025 EAW65026 Q9BWF2 AB451320 BAG70134 AB451449 BAG70263 AK225873 AK292172 BAF84861 AK295780 BAG58603 BC000310 AAH00310 BC019283 AAH19283 BQ446539 BX473682 EF036504 ABO65090 HQ448174 ADQ32655 U77845 AAB52993 XM_011533264 XP_011531566 XR_940361 NM_005879 NP_005870
|
| Function |
Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity. {ECO:0000250, ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta.
|