| Gene Symbol | AKR1C4 |
|---|---|
| Entrez Gene | 1109 |
| Alt Symbol | 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldo-keto reductase family 1, member C4 |
| Other Description | 3-alpha-HSD1|aldo-keto reductase family 1 member C4|chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4|dihydrodiol dehydrogenase isozyme DD4|type I 3-alpha-hydroxysteroid dehydrogenase |
| Swissprots | Q5T6A3 Q8WW84 Q9NS54 P17516 |
| Accessions | AAB47003 BAA92893 BAB43901 CBX51394 EAW86450 P17516 AB031085 BAA92885 AB045829 BAA99542 AK314988 BC020744 AAH20744 D26125 BAA05122 DQ891424 ABM82350 DQ894598 ABM85524 M33375 AAA35658 S68287 AAD14010 XM_011519303 XP_011517605 NM_001818 NP_001809 |
| Function | Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Liver specific. {ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}. |
| Top Pathways | Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450 |