AKR1C4

Gene Symbol AKR1C4
Entrez Gene 1109
Alt Symbol 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C4
Other Description 3-alpha-HSD1|aldo-keto reductase family 1 member C4|chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4|dihydrodiol dehydrogenase isozyme DD4|type I 3-alpha-hydroxysteroid dehydrogenase
Swissprots Q5T6A3 Q8WW84 Q9NS54 P17516
Accessions AAB47003 BAA92893 BAB43901 CBX51394 EAW86450 P17516 AB031085 BAA92885 AB045829 BAA99542 AK314988 BC020744 AAH20744 D26125 BAA05122 DQ891424 ABM82350 DQ894598 ABM85524 M33375 AAA35658 S68287 AAD14010 XM_011519303 XP_011517605 NM_001818 NP_001809
Function Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Subcellular Location Cytoplasm.
Tissue Specificity Liver specific. {ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}.
Top Pathways Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

DD4 CRISPR/Cas9 KO Plasmid (h) - sc-403692 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 HDR Plasmid (h) - sc-403692-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 Double Nickase Plasmid (h) - sc-403692-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 Double Nickase Plasmid (h2) - sc-403692-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 CRISPR Activation Plasmid (h) - sc-403692-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 CRISPR Activation Plasmid (h2) - sc-403692-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 Lentiviral Activation Particles (h) - sc-403692-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 Lentiviral Activation Particles (h2) - sc-403692-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD4 siRNA (h) - sc-44463 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DD4 shRNA Plasmid (h) - sc-44463-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DD4 shRNA (h) Lentiviral Particles - sc-44463-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Aldo-keto Reductase 1C4/AKR1C4 RNAi - H00001109-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU127441 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3029 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3029 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11963 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11963

AKR1C4 siRNA (Human) - CRH0791 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AKR1C4 - MBS8201463 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AKR1C4 (NM_001818.3) - SHH234570 from Creative biogene

Category siRNA
Species Reactivities Human

Human AKR1C4 siRNA - orb261293 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AKR1C4 shRNA Plasmid (Human) - CHH0791 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AKR1C4 miRNA 3'UTR clone - MiUTR3H-03389 from Creative biogene

Species Reactivities Human
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