AKR1C4

Gene Symbol AKR1C4
Entrez Gene 1109
Alt Symbol 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C4
Other Description 3-alpha-HSD1|aldo-keto reductase family 1 member C4|chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4|dihydrodiol dehydrogenase isozyme DD4|type I 3-alpha-hydroxysteroid dehydrogenase
Swissprots Q5T6A3 Q8WW84 Q9NS54 P17516
Accessions AAB47003 BAA92893 BAB43901 CBX51394 EAW86450 P17516 AB031085 BAA92885 AB045829 BAA99542 AK314988 BC020744 AAH20744 D26125 BAA05122 DQ891424 ABM82350 DQ894598 ABM85524 M33375 AAA35658 S68287 AAD14010 XM_011519303 XP_011517605 NM_001818 NP_001809
Function Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Subcellular Location Cytoplasm.
Tissue Specificity Liver specific. {ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}.
Top Pathways Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

AKR1C4-Over-expression-Lysate - LY12319a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag AKR1C4 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AKR1C4 gene

AKR1C4 293T Cell Transient Overexpression Lysate(Denatured) - H00001109-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

AKR1C4 overexpression lysate - LY419725 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

AKR1C4 293 Cell Lysate - 409234 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Aldo-keto Reductase 1C4/AKR1C4 Overexpression Lysate (Denatured) - H00001109-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Western Blot: AKR1C4 Overexpression Lysate [H00001109-T01] - Lane 1: AKR1C4 transfected lysate (35.64 KDa) Lane 2: Non-transfected lysate.

Aldo-keto Reductase 1C4/AKR1C4 Overexpression Lysate (Native) - NBL1-07437 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: AKR1C4 Overexpression Lysate (Adult Normal) [NBL1-07437] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AKR1C4.

DD4 (h): 293T Lysate - sc-173413 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

AKR1C4 Over-expression Lysate Product - GWB-5F8254 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human AKR1C4 Knockdown Stable Cell Line - CSC-DC000459 from Creative biogene

Category Cell Line
Species Human
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