AKR1C4

Gene Symbol	AKR1C4
Entrez Gene	1109
Alt Symbol	3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C4
Other Description	3-alpha-HSD1|aldo-keto reductase family 1 member C4|chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4|dihydrodiol dehydrogenase isozyme DD4|type I 3-alpha-hydroxysteroid dehydrogenase
Swissprots	Q5T6A3 Q8WW84 Q9NS54 P17516
Accessions	AAB47003 BAA92893 BAB43901 CBX51394 EAW86450 P17516 AB031085 BAA92885 AB045829 BAA99542 AK314988 BC020744 AAH20744 D26125 BAA05122 DQ891424 ABM82350 DQ894598 ABM85524 M33375 AAA35658 S68287 AAD14010 XM_011519303 XP_011517605 NM_001818 NP_001809
Function	Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Subcellular Location	Cytoplasm.
Tissue Specificity	Liver specific. {ECO:0000269|PubMed:11158055, ECO:0000269|PubMed:7650035}.
Top Pathways	Primary bile acid biosynthesis, Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HSD3a full length protein - ab168003 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human HSD3a full length protein - ab109831 from Abcam Category Protein Prices $302.00, $883.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human HSD3a full length protein - ab172176 from Abcam Category Protein Source E. coli Species Human

Human HSD3a peptide - ab50442 from Abcam Category Peptide Species Human

AKR1C4 / Chlordecone Reductase Antibody Blocking Peptide - LS-E4126 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKR1C4 / Chlordecone Reductase Antibody Blocking Peptide - LS-E26091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Aldo-keto Reductase 1C4/AKR1C4 Recombinant Protein - H00001109-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Aldo-keto Reductase 1C4/AKR1C4 Protein - NBP1-72352 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

AKR1C4-Antibody-N-term-Blocking-Peptide - BP16366a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HSD3a blocking peptide - GTX89330-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Aldo-keto Reductase 1C4/AKR1C4, CF - 6957-DH-020 from R&D Systems Category Protein Source E. coli-derived, Met1-Tyr323

Human AKR1C4 protein (His Tag) - orb138148 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human AKR1C4 protein - orb167875 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

ANKRA2 protein (His tag) - 80R-3920 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

HSD3a Peptide - AC21-0919-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AKR1C4 (1-323, His-tag) - AR39046PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

AKR1C4 (1-323, His-tag) - AR39046PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

AKR1C4 - H00001109-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1C4 - H00001109-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Aldo-Keto Reductase Family 1 Member C4, Human Recombinant - 228-12296-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Aldo-Keto Reductase Family 1 Member C4 - 228-12296-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Aldo-Keto Reductase Family 1 Member C4 - 228-12296-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

AKR1C4, 1-323aa, Human, His tag, E.coli - 01-2026-4 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Aldo-keto Reductase 1C4, AKR1C4, Human, Recombinant - 19-CE36 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

AKR1C4 Peptide - 45-236P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

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