RIC3

Gene Symbol RIC3
Entrez Gene 79608
Alt Symbol AYST720, PRO1385
Species Human
Gene Type protein-coding
Description RIC3 acetylcholine receptor chaperone
Other Description protein RIC-3|resistance to inhibitors of cholinesterase 3 homolog|resistant to inhibitor of cholinesterase 3
Swissprots B0B1U0 Q8TBJ9 Q7Z5B3 Q9HAH8 B2RD25 D3DQU5 Q6UX78 Q86T94 Q7Z5B4
Accessions CAE90186 EAW68627 EAW68628 EAW68629 EAW68630 EAW68631 Q7Z5B4 AK021670 BAB13871 AK022297 AK128611 AK293933 BAH11630 AK296505 BAH12376 AK315379 BAG37772 AL390131 AL832601 CAD89943 AM422214 CAM12309 AY326435 AAP92162 AY326436 AAP92163 AY358475 AAQ88839 BC022455 AAH22455 BQ941375 BX647514 CB850751 DA186330 DC420812 DQ347704 DQ347705 XM_006718317 XP_006718380 XM_006718318 XP_006718381 XM_006718321 XP_006718384 XM_011520366 XP_011518668 XR_428848 XR_428851 XR_930896 XR_930897 XR_930898 XR_930899 XR_930900 XR_930901 XR_930902 XR_930903 XR_930904 XR_930905 XR_930906 NM_001135109 NP_001128581 NM_001206671 NP_001193600 NM_001206672 NP_001193601 NM_024557 NP_078833 NR_045405
Function Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:15504725, ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:15927954, ECO:0000269|PubMed:16120769, ECO:0000269|PubMed:17609200, ECO:0000269|PubMed:18691158}.
Subcellular Location Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:17640815, ECO:0000269|PubMed:18691158}.

RIC-3 (C-17) - sc-54140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RIC-3 (C-17): sc-54140. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

RIC-3 (G-8) - sc-377408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RIC-3 (G-8): sc-377408. Western blot analysis of RIC-3 expression in non-transfected (A) and human RIC-3 transfected (B) CMV whole cell lysates.

RIC-3 (H-282) - sc-134787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RIC-3 (H-282): sc-134787. Western blot analysis of RIC-3 expression in NCI-H292 (A), PC-12 (B) and SH-SY5Y (C) whole cell lysates.

RIC-3 (Q-18) - sc-54141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RIC-3 (W-16) - sc-54143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RIC-3 (V-19) - sc-54142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RIC-3 (V-19): sc-54142. Western blot analysis of RIC-3 expression in A549 (A) and WiDR (B) whole cell lysates.

Anti-RIC3 antibody - ab112911 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RIC3 antibody (ab112911) at 1/100 dilution + NCI-H292 Cell Lysate at 35 µg

Anti-RIC3 Antibody (aa313-341, Biotin) - LS-C207575 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341, APC) - LS-C207574 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341, AP) - LS-C207573 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341, FITC) - LS-C207576 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341, Azide-free, HRP) - LS-C207586 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341, PE) - LS-C209027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa319-348) - LS-C324678 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC3 Antibody (aa313-341) - LS-C162602 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RIC3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

RIC3 Antibody - H00079608-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RIC3 Antibody [H00079608-B01P] - Analysis of RIC3 expression in transfected 293T cell line by RIC3 polyclonal antibody. Lane 1: RIC3 transfected lysate(40.48 KDa). Lane 2: Non-transfected lysate.

RIC3 Antibody - NBP2-38058 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: RIC3 Antibody [NBP2-38058] - Staining of human pancreas shows strong granular cytoplasmic positivity in exocrine glandular cells.

Anti-RIC3 (331-345) antibody produced in rabbit - SAB1101891 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human RIC3 was separated on SDS-PAGE, blotted with Anti-RIC3 (331-345) (<B>Cat. No. SAB1101891</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500 <BR/>2. Antibody dilution 1:500 + RIC3 immunizing peptide (human,331-345)

Anti-RIC3 (221-235) antibody produced in rabbit - SAB1101890 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human RIC3 was separated on SDS-PAGE, blotted with Anti-RIC3 (221-235) (<B>Cat. No. SAB1101890</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500 <BR/>2. Antibody dilution 1:500 + RIC3 immunizing peptide (human,221-235)

Anti-RIC3 antibody produced in mouse - SAB1401823 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-RIC3, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401823</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~40.48 kDa using RIC3 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

RIC3-Antibody-C-term - AP12721b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
RIC3 Antibody (C-term) (Cat. #AP12721b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RIC3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

RIC3 Antibody - C-terminal region (OAAB09003) - OAAB09003 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

RIC3 antibody - 70R-19894 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

RIC3 Antibody - abx026974 from Abbexa

Host Rabbit
Clonality Polyclonal

RIC3 (C-term) antibody - AP53664PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed, paraffin embedded human brain tissue stained with RIC3 Antibody (C-term) Cat.-No AP53664PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining.
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