| Gene Symbol |
KDM8
|
| Entrez Gene |
79831
|
| Alt Symbol |
JMJD5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 8
|
| Other Description |
jmjC domain-containing protein 5|jumonji domain containing 5|jumonji domain-containing protein 5|lysine-specific demethylase 8
|
| Swissprots |
Q9H8B1 B4DLU9 Q8N371 Q6VAK5
|
| Accessions |
EAW55759 Q8N371 AK023860 BAB14706 AK225066 AK297166 BAG59661 AK298410 BAG60638 AK308499 AK310885 AY345239 AAQ23080 BC027911 AAH27911 BQ022832 DA497245 JF432533 ADZ15750 XM_006721092 XP_006721155 XM_011545950 XP_011544252 XM_011545951 XP_011544253 NM_001145348 NP_001138820 NM_024773 NP_079049
|
| Function |
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. {ECO:0000269|PubMed:20457893}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20457893}.
|
| Tissue Specificity |
Weakly expressed in most cells. Highly expressed in breast cancer cells. {ECO:0000269|PubMed:20457893}.
|
![Western Blot: JMJD5 Overexpression Lysate (Adult Normal) [NBL1-12106] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JMJD5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3023_JMJD5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12106-img0002.jpg)
![Western Blot: JMJD5 Overexpression Lysate (Adult Normal) [NBP2-09744] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JMJD5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6548_JMJD5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09744-img0001.jpg)