| Gene Symbol | ADAMTS4 |
|---|---|
| Entrez Gene | 9507 |
| Alt Symbol | ADAMTS-2, ADAMTS-4, ADMP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
| Other Description | A disintegrin and metalloproteinase with thrombospondin motifs 4|ADAM-TS 4|ADAM-TS4|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1 |
| Swissprots | Q5VTW2 Q2HYD0 Q6P4Q8 Q6UWA8 O75173 Q9UN83 |
| Accessions | AAL02262 EAW52627 O75173 AB014588 BAA31663 AF148213 AAD41494 AK291573 BAF84262 AL603427 AY358886 AAQ89245 BC030812 BC063293 AAH63293 DA098917 DQ364570 ABC88384 XM_006711635 XP_006711698 NM_005099 NP_005090 |
| Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. {ECO:0000269|PubMed:23897278}. |
Human ADAMTS4 ELISA Kit (Sandwich ELISA) - LS-F7250 from LifeSpan Bioscience
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Rat ADAMTS4 ELISA Kit (Sandwich ELISA) - LS-F9386 from LifeSpan Bioscience
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Human ADAMTS4 ELISA Kit (Sandwich ELISA) - LS-F10525 from LifeSpan Bioscience
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Rat ADAMTS4 ELISA Kit (Sandwich ELISA) - LS-F10900 from LifeSpan Bioscience
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ADAMTS4 Colorimetric Assay Kit - KA1498 from Novus Biologicals
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ADAMTS4 Colorimetric Assay Kit - KA1497 from Novus Biologicals
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Human ADAMTS4 ELISA Kit - abx150553 from Abbexa
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Human ADAMTS4 ELISA Kit - abx054910 from Abbexa
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A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4), Human, ELISA Kit - SEK204Hu from ARP American Research Products
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A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3), Human, ELISA Kit - CSB-EL001310HU from ARP American Research Products
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A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), Human, ELISA Kit - E01A0940 from ARP American Research Products
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A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAMTS4, Human, ELISA Kit - E1804h from ARP American Research Products
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ADAM metallopeptidase with thrombospondin type 1 motif4, ADAMTS4, Human, ELISA Kit - CSB-E11848h from ARP American Research Products
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ADAM with Thrombospondin Type 1 Motif 4, ADAMTS4, Human, ELISA Kit - E-EL-H0266 from ARP American Research Products
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ADAM with Thrombospondin Type 1 Motif4, ADAMTS4, Rabbit, ELISA Kit - E-EL-RB1004 from ARP American Research Products
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ADAM with Thrombospondin Type 1 Motif4, ADAMTS4, Chicken, ELISA Kit - E-EL-Ch1675 from ARP American Research Products
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ADAM with Thrombospondin Type 1 Motif4, ADAMTS4, Porcine, ELISA Kit - E-EL-P0907 from ARP American Research Products
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ADAM with Thrombospondin Type 1 Motif4, ADAMTS4, Monkey, ELISA Kit - E-EL-MK1126 from ARP American Research Products
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ADAMTS4 (Human) IP-WB Antibody Pair - H00009507-PW1 from Acris Antibodies
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ADAMTS4 (Human) IP-WB Antibody Pair - H00009507-PW2 from Acris Antibodies
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Custom Human ADAMTS-4 ELISA - ELH-ADAMTS4 from RayBiotech
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Human ADAMTS4 ELISA Kit - HD0023 from NeoScientific
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Anserine ADAMTS4 ELISA Kit - AD0023 from NeoScientific
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A disintegrin and metalloproteinase with thrombospondin motifs 4, ELISA Kit - MBS282450 from MyBioSource
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A disintegrin and metalloproteinase with thrombospondin motifs 4, ELISA Kit - MBS177535 from MyBioSource
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