ADAMTS4

Gene Symbol	ADAMTS4
Entrez Gene	9507
Alt Symbol	ADAMTS-2, ADAMTS-4, ADMP-1
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 4
Other Description	A disintegrin and metalloproteinase with thrombospondin motifs 4|ADAM-TS 4|ADAM-TS4|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
Swissprots	Q5VTW2 Q2HYD0 Q6P4Q8 Q6UWA8 O75173 Q9UN83
Accessions	AAL02262 EAW52627 O75173 AB014588 BAA31663 AF148213 AAD41494 AK291573 BAF84262 AL603427 AY358886 AAQ89245 BC030812 BC063293 AAH63293 DA098917 DQ364570 ABC88384 XM_006711635 XP_006711698 NM_005099 NP_005090
Function	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity	Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. {ECO:0000269|PubMed:23897278}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ADAMTS4 peptide - ab41235 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAMTS4 peptide - ab41236 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAMTS4 peptide - ab45232 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human ADAMTS4 full length protein - ab132081 from Abcam Category Protein Source Wheat germ Species Human

Human ADAMTS4 protein fragment - ab152993 from Abcam Category Protein Source Wheat germ Species Human

ADAMTS4 Antibody Blocking Peptide - LS-E8955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADAMTS4 Antibody Blocking Peptide - LS-E28318 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E28319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E28322 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E28321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E29284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E29285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAMTS4 Antibody Blocking Peptide - LS-E15297 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ADAMTS4 Protein - H00009507-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ADAMTS4 Recombinant Protein - H00009507-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ADAMTS4-Antibody-C-term-Blocking-Peptide - BP7439b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ADAMTS4, CF - 4307-AD-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Phe213-Cys685, with a C-terminal 10-His tag

ADAMTS4 Blocking Peptide - 33R-3654 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human ADAMTS4 Protein - abx065078 from Abbexa Category Protein Source E.coli Species Human

ADAMTS4 - H00009507-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ADAMTS4 - H00009507-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ADAMTS4 - H00009507-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ADAMTS4 - H00009507-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ADAMTS4 control peptide - SP5183CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4), Human - 20-9422 from ARP American Research Products Category Protein Prices $469.00 Sizes 50 µg Source E.coli Species Human

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