ADAMTS4

Gene Symbol ADAMTS4
Entrez Gene 9507
Alt Symbol ADAMTS-2, ADAMTS-4, ADMP-1
Species Human
Gene Type protein-coding
Description ADAM metallopeptidase with thrombospondin type 1 motif, 4
Other Description A disintegrin and metalloproteinase with thrombospondin motifs 4|ADAM-TS 4|ADAM-TS4|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
Swissprots Q5VTW2 Q2HYD0 Q6P4Q8 Q6UWA8 O75173 Q9UN83
Accessions AAL02262 EAW52627 O75173 AB014588 BAA31663 AF148213 AAD41494 AK291573 BAF84262 AL603427 AY358886 AAQ89245 BC030812 BC063293 AAH63293 DA098917 DQ364570 ABC88384 XM_006711635 XP_006711698 NM_005099 NP_005090
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. {ECO:0000269|PubMed:23897278}.

ADAMTS-4 CRISPR/Cas9 KO Plasmid (h) - sc-403133 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 HDR Plasmid (h) - sc-403133-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 Double Nickase Plasmid (h) - sc-403133-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 Double Nickase Plasmid (h2) - sc-403133-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 CRISPR Activation Plasmid (h) - sc-403133-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 CRISPR Activation Plasmid (h2) - sc-403133-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 Lentiviral Activation Particles (h) - sc-403133-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 Lentiviral Activation Particles (h2) - sc-403133-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ADAMTS-4 siRNA (h) - sc-41428 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ADAMTS-4 shRNA Plasmid (h) - sc-41428-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ADAMTS-4 shRNA (h) Lentiviral Particles - sc-41428-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2835 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2835 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ADAMTS4 siRNA (Human) - CRH6314 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ADAMTS4 RNAi - H00009507-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ADAMTS4 - MBS8214679 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ADAMTS4 (NM_005099.4) - SHH231874 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ADAMTS4(NM_005099.4) - SHG040057 from Creative biogene

Category siRNA
Species Reactivities Human

Human ADAMTS4 siRNA - orb266816 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ADAMTS4 shRNA Plasmid (Human) - CHH6314 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ADAMTS4 miRNA 3'UTR clone - MiUTR1H-00174 from Creative biogene

Species Reactivities Human
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