ADAMTS4

Gene Symbol	ADAMTS4
Entrez Gene	9507
Alt Symbol	ADAMTS-2, ADAMTS-4, ADMP-1
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 4
Other Description	A disintegrin and metalloproteinase with thrombospondin motifs 4|ADAM-TS 4|ADAM-TS4|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
Swissprots	Q5VTW2 Q2HYD0 Q6P4Q8 Q6UWA8 O75173 Q9UN83
Accessions	AAL02262 EAW52627 O75173 AB014588 BAA31663 AF148213 AAD41494 AK291573 BAF84262 AL603427 AY358886 AAQ89245 BC030812 BC063293 AAH63293 DA098917 DQ364570 ABC88384 XM_006711635 XP_006711698 NM_005099 NP_005090
Function	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity	Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. {ECO:0000269|PubMed:23897278}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat ADAMTS4 (NP_076449) VersaClone cDNA - RDC1009 from R&D Systems Prices $499.00 Sizes 10 µg Species Rat

ADAMTS4 - MBS1268624 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC030812

Human ADAMTS4 ORF Clone(NM_005099.4) - CDCL153144 from Creative Biomart Species Human Accession NM_005099.4

Human ADAMTS4 ORF clone(NM_005099.4) - CDCL182591 from Creative Biomart Species Human Accession NM_005099.4

Human ADAMTS4 Gene ORF cDNA clone in cloning vector - HG11024-M from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11024-NF from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11024-NM from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11024-CF from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11024-ACR from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11024-CM from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11024-CY from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11024-NY from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, N-His tag - HG11024-NH from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid - HG11024-UT from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-His tag - HG11024-CH from Sino Biological Species Human

Human ADAMTS4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11024-ACG from Sino Biological Species Human

Human ADAMTS4 ORF clone(NM_005099.4) - CDCL182591 from Creative biogene Species Human

Human ADAMTS4 ORF Clone (BC030812) - CDCS412096 from Creative biogene Species Human Accession O75173

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