ADAMTS4

Gene Symbol ADAMTS4
Entrez Gene 9507
Alt Symbol ADAMTS-2, ADAMTS-4, ADMP-1
Species Human
Gene Type protein-coding
Description ADAM metallopeptidase with thrombospondin type 1 motif, 4
Other Description A disintegrin and metalloproteinase with thrombospondin motifs 4|ADAM-TS 4|ADAM-TS4|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4|aggrecanase-1
Swissprots Q5VTW2 Q2HYD0 Q6P4Q8 Q6UWA8 O75173 Q9UN83
Accessions AAL02262 EAW52627 O75173 AB014588 BAA31663 AF148213 AAD41494 AK291573 BAF84262 AL603427 AY358886 AAQ89245 BC030812 BC063293 AAH63293 DA098917 DQ364570 ABC88384 XM_006711635 XP_006711698 NM_005099 NP_005090
Function Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2 is detected in osteoarthritic synovium. {ECO:0000269|PubMed:23897278}.

ADAMTS-2 (H-121) - sc-134655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ADAMTS-2 (H-121): sc-134655. Western blot analysis of ADAMTS-2 expression in non-transfected: sc-117752 (A) and mouse ADAMTS-2 transfected: sc-124925 (B) 293T whole cell lysates.

ADAMTS-2 (M-123) - sc-134656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ADAMTS-2 (M-123): sc-134656. Western blot analysis of ADAMTS-2 expression in non-transfected: sc-117752 (A) and mouse ADAMTS-2 transfected: sc-124925 (B) 293T whole cell lysates.

ADAMTS-4 (H-74) - sc-25582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ADAMTS-4 (K-20) - sc-16533 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAMTS-4 (K-20): sc-16533. Western blot analysis of ADAMTS-4 expression in non-transfected 293T: sc-117752 (A), human FLRT1 transfected 293T: sc-373571 (B) and NCI-H1299 (C) whole cell lysates.

ADAMTS-4 (Y-20) - sc-16534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ADAMTS4 antibody - ab45038 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAMTS4 antibody (ab45038) at 1/1000 dilutionLane 1 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with SF) Lane 2 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with TPA) Lane 3 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with IL1-alpha) Lane 4 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with IL1-beta) Lane 5 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with TNA-alpha) Lane 6 : Whole cell lysate prepared from rat osteosarcoma UMR 106 cells (treated with RA)

Anti-ADAMTS4 antibody - ab84792 from Abcam

Prices $379.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAMTS4 antibody (ab84792) at 1/1000 dilution + Human fetal brain lysates

Anti-ADAMTS4 antibody - ab39201 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 antibody [MM0081-10D5] - ab89112 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0081-10D5

Anti-ADAMTS4 antibody - C-terminal - ab82300 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAMTS4 antibody - C-terminal (ab82300) at 1/50 dilution + mouse cerebellum tissue lysate at 35 µg

Anti-ADAMTS4 antibody - Carboxyterminal end - ab28285 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody - LS-C63662 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ADAMTS4 Antibody (C-Terminus) - LS-C122607 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa213-685, Biotin) - LS-C124922 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa213-685) - LS-C124923 from LifeSpan Bioscience

Prices $620.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-ADAMTS4 Antibody (C-Terminus) - LS-C126606 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa876-893) - LS-C126607 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (C-Terminus) - LS-C126608 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (C-Terminus, Magnetic beads) - LS-C172046 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (C-Terminus, Sepharose) - LS-C172047 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa56-105) - LS-C151224 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADAMTS4 antibody Western Blot of Rat Kidney.

Anti-ADAMTS4 Antibody (C-Terminus) - LS-C172045 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa713-743, AP) - LS-C218575 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa713-743, APC) - LS-C218576 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADAMTS4 Antibody (aa713-743, FITC) - LS-C218577 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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