COLEC12

Gene Symbol	COLEC12
Entrez Gene	81035
Alt Symbol	CLP1, NSR2, SCARA4, SRCL
Species	Human
Gene Type	protein-coding
Description	collectin sub-family member 12
Other Description	collectin placenta protein 1\|collectin-12\|hCL-P1\|nurse cell scavenger receptor 2\|scavenger receptor class A, member 4\|scavenger receptor with C-type lectin
Swissprots	Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2
Accessions	EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781
Function	Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269\|PubMed:11162630, ECO:0000269\|PubMed:11564734, ECO:0000269\|PubMed:12761161, ECO:0000269\|PubMed:15845541, ECO:0000269\|PubMed:16868960}.
Subcellular Location	Membrane {ECO:0000269\|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269\|PubMed:11162630}. Note=Forms clusters on the cell surface.
Tissue Specificity	Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269\|PubMed:11162630, ECO:0000269\|PubMed:11564734, ECO:0000269\|PubMed:12761161, ECO:0000269\|PubMed:16868960}.
Top Pathways	Phagosome

CL-P1 (A-22) - sc-133462 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Rabbit
Clonality	Polyclonal

CL-P1 (A-22): sc-133462. Western blot analysis of CL-P1 expression in Jurkat whole cell lysate.

CL-P1 (H-300) - sc-366969 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CL-P1 (T-20) - sc-84794 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CL-P1 (T-20): sc-84794. Western blot analysis of CL-P1 expression in A549 (A), Jurkat (B) and K-562 (C) whole cell lysates.

Anti-COLEC12 Antibody (aa70-100, AP) - LS-C255206 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100, APC) - LS-C255208 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100, Biotin) - LS-C255209 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100, FITC) - LS-C255210 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100, Azide-free, HRP) - LS-C255211 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100, PE) - LS-C255212 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa101-201) - LS-C307036 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-COLEC12 Antibody (aa70-100) - LS-C320509 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa70-100) - LS-C159383 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

COL12 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The COL12 antibody detected the COL12 protein (arrow).

Anti-COLEC12 Antibody (aa103-152) - LS-C29752 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-COLEC12 Antibody (aa481-530) - LS-C81544 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-COLEC12 Antibody (aa101-150) - LS-C81543 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

CL-P1/COLEC12 Antibody - AF2690 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

CL-P1/COLEC12 Antibody (388305) - MAB26901 from Novus Biologicals

Prices	$99.00, $249.00
Sizes	25 µg, 100 µg
Host	Rat
Clonality	Monoclonal
Clone	388305

Colec12 Antibody - NBP2-33508 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: Colec12 Antibody [NBP2-33508] - Staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.

Colec12 Antibody - NBP2-15944 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Colec12 Antibody [NBP2-15944] - Sample (30 ug of whole cell lysate) A: Raji B: K562 5% SDS PAGE diluted at 1:2000

Colec12 Antibody - NBP1-59015 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Colec12 Antibody - NBP1-59014 from Novus Biologicals

Prices	$369.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Colec12 Antibody [NBP1-59014] - 721_B cell lysate, concentration 0.2-1 ug/ml.

Colec12 Antibody - H00081035-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Colec12 Antibody [H00081035-B01] - COLEC12 MaxPab polyclonal antibody (B01), Lot # 07340 WULz. Western Blot analysis of COLEC12 expression in human placenta.

Colec12 Antibody - H00081035-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Colec12 Antibody [H00081035-A01] - COLEC12 polyclonal antibody (A01), Lot # 050913JC01 Western Blot analysis of COLEC12 expression in SJCRH30 ( Cat # L027V1 ).

Colec12 Antibody (4A7) - H00081035-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	4A7

Western Blot: Colec12 Antibody (4A7) [H00081035-M01] - COLEC12 monoclonal antibody (M01), clone 4A7. Analysis of COLEC12 expression in JAR.

COLEC12 Polyclonal Antibody - bs-2541R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded human placenta labeled with Anti-COLEC12 Polyclonal Antibody, Unconjugated (bs-2541R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

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