Gene Symbol | COLEC12 |
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Entrez Gene | 81035 |
Alt Symbol | CLP1, NSR2, SCARA4, SRCL |
Species | Human |
Gene Type | protein-coding |
Description | collectin sub-family member 12 |
Other Description | collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin |
Swissprots | Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2 |
Accessions | EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781 |
Function | Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface. |
Tissue Specificity | Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}. |
Top Pathways | Phagosome |
CL-P1 CRISPR/Cas9 KO Plasmid (h) - sc-409335 from Santa Cruz Biotechnology
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CL-P1 HDR Plasmid (h) - sc-409335-HDR from Santa Cruz Biotechnology
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CL-P1 Double Nickase Plasmid (h) - sc-409335-NIC from Santa Cruz Biotechnology
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CL-P1 Double Nickase Plasmid (h2) - sc-409335-NIC-2 from Santa Cruz Biotechnology
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CL-P1 CRISPR Activation Plasmid (h) - sc-409335-ACT from Santa Cruz Biotechnology
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CL-P1 CRISPR Activation Plasmid (h2) - sc-409335-ACT-2 from Santa Cruz Biotechnology
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CL-P1 Lentiviral Activation Particles (h) - sc-409335-LAC from Santa Cruz Biotechnology
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CL-P1 Lentiviral Activation Particles (h2) - sc-409335-LAC-2 from Santa Cruz Biotechnology
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CL-P1 siRNA (h) - sc-72913 from Santa Cruz Biotechnology
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CL-P1 shRNA Plasmid (h) - sc-72913-SH from Santa Cruz Biotechnology
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CL-P1 shRNA (h) Lentiviral Particles - sc-72913-V from Santa Cruz Biotechnology
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CL-P1/COLEC12 RNAi - H00010978-R01 from Novus Biologicals
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Colec12 RNAi - H00081035-R04 from Novus Biologicals
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MISSION® esiRNA - EHU025431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6411 from Sigma-Aldrich
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COLEC12 siRNA (Human) - CRJ2949 from Cohesion Biosciences
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Colec12 RNAi - H00081035-R03 from Novus Biologicals
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COLEC12 - MBS8241099 from MyBioSource
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shRNA set against Human Colec12 (NM_130386.2) - SHH267533 from Creative biogene
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Human COLEC12 siRNA - orb273450 from Biorbyt
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COLEC12 shRNA Plasmid (Human) - CHJ2949 from Cohesion Biosciences
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COLEC12 miRNA 3'UTR clone - MiUTR3H-09350 from Creative biogene
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