COLEC12

Gene Symbol COLEC12
Entrez Gene 81035
Alt Symbol CLP1, NSR2, SCARA4, SRCL
Species Human
Gene Type protein-coding
Description collectin sub-family member 12
Other Description collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin
Swissprots Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2
Accessions EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781
Function Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.
Subcellular Location Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
Tissue Specificity Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}.
Top Pathways Phagosome

CL-P1 CRISPR/Cas9 KO Plasmid (h) - sc-409335 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 HDR Plasmid (h) - sc-409335-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 Double Nickase Plasmid (h) - sc-409335-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 Double Nickase Plasmid (h2) - sc-409335-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 CRISPR Activation Plasmid (h) - sc-409335-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 CRISPR Activation Plasmid (h2) - sc-409335-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 Lentiviral Activation Particles (h) - sc-409335-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 Lentiviral Activation Particles (h2) - sc-409335-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CL-P1 siRNA (h) - sc-72913 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CL-P1 shRNA Plasmid (h) - sc-72913-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CL-P1 shRNA (h) Lentiviral Particles - sc-72913-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CL-P1/COLEC12 RNAi - H00010978-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Colec12 RNAi - H00081035-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU025431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6411 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6411 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COLEC12 siRNA (Human) - CRJ2949 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Colec12 RNAi - H00081035-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

COLEC12 - MBS8241099 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Colec12 (NM_130386.2) - SHH267533 from Creative biogene

Category siRNA
Species Reactivities Human

Human COLEC12 siRNA - orb273450 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COLEC12 shRNA Plasmid (Human) - CHJ2949 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COLEC12 miRNA 3'UTR clone - MiUTR3H-09350 from Creative biogene

Species Reactivities Human
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