COLEC12

Gene Symbol	COLEC12
Entrez Gene	81035
Alt Symbol	CLP1, NSR2, SCARA4, SRCL
Species	Human
Gene Type	protein-coding
Description	collectin sub-family member 12
Other Description	collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin
Swissprots	Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2
Accessions	EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781
Function	Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.
Subcellular Location	Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
Tissue Specificity	Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}.
Top Pathways	Phagosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Colec12 full length protein - ab164315 from Abcam Category Protein Source Wheat germ Species Human

Human Colec12 protein fragment - ab164316 from Abcam Category Protein Source Wheat germ Species Human

CLP1 Antibody Blocking Peptide - LS-E4764 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLP1 Antibody Blocking Peptide - LS-E23413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLP1 Antibody Blocking Peptide - LS-E23412 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COLEC12 Antibody Blocking Peptide - LS-E5630 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COLEC12 Antibody Blocking Peptide - LS-E18164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COLEC12 Antibody Blocking Peptide - LS-E18165 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COLEC12 Antibody Blocking Peptide - LS-E11390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Colec12 Protein - H00081035-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Colec12 Protein - H00081035-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CL-P1/COLEC12 Protein - H00010978-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CL-P1/COLEC12 Partial Recombinant Protein - H00010978-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

COL12-Antibody-N-term-Blocking-Peptide - BP18157a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CL-P1/COLEC12, CF - 2690-CL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu57-Leu742, with an N-terminal 9-His tag

Cynomolgus CLP1 protein - orb138609 from Biorbyt Category Protein Prices $238.00, $400.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells

COLEC12 Blocking Peptide - 33R-1281 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COLEC12 Blocking Peptide - 33R-1195 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

COLEC12 Blocking Peptide - 33R-3392 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Collectin-12 - H00081035-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Collectin-12 - H00081035-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Collectin-12 - H00081035-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Collectin-12 - H00081035-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COLEC12 fusion protein - ag5933 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

COLEC12 fusion protein - ag5066 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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