| Gene Symbol |
COLEC12
|
| Entrez Gene |
81035
|
| Alt Symbol |
CLP1, NSR2, SCARA4, SRCL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
collectin sub-family member 12
|
| Other Description |
collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin
|
| Swissprots |
Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2
|
| Accessions |
EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781
|
| Function |
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
|
| Tissue Specificity |
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}.
|
| Top Pathways |
Phagosome
|
![Western Blot: Colec12 Overexpression Lysate (Adult Normal) [NBL1-09363] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Colec12.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9920_Colec12%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09363-img0002.jpg)