COLEC12

Gene Symbol COLEC12
Entrez Gene 81035
Alt Symbol CLP1, NSR2, SCARA4, SRCL
Species Human
Gene Type protein-coding
Description collectin sub-family member 12
Other Description collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin
Swissprots Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2
Accessions EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781
Function Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.
Subcellular Location Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface.
Tissue Specificity Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}.
Top Pathways Phagosome

Collectin-12 (COLEC12), Human, ELISA Kit - CSB-EL005762HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Collectin-12 (COLEC12), Human, ELISA Kit - E01C1927 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Protein HEXIM1 (HEXIM1), Human, ELISA Kit - CSB-EL010318HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Collectin 12 (COLEC12), ELISA Kit - MBS7246655 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

collectin sub-family member 12, ELISA Kit - MBS907179 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human COLEC12 is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.312 ng/ml -20 ng/ml.

Human Collectin-12(COLEC12) ELISA kit - CSB-EL005762HU from Cusabio

Category ELISA Kit
Sensitivity 0.078 ng/ml.
Range 0.312 ng/ml-20 ng/ml

Custom Human Collectin-12 ELISA - ELH-COLEC12 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Collectin-12 ELISA Kit - orb319923 from Biorbyt

Category ELISA Kit
Prices $1,148.00, $1,981.00, $4,284.00
Sizes 96 assays, 192 assays, 480 assays

Human Collectin-12 ELISA - RAB1387 from Sigma-Aldrich

Prices $615.00
Sizes 1 kt

Human Collectin-12 (COLEC12) ELISA Kit - EKC33234 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml-20 ng/ml

Custom Human Collectin-12 ELISA - ELH-COLEC12-1 from RayBiotech

Category ELISA Kit
Prices $627.00, $1,128.60, $2,508.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human CLP1 ELISA Kit - E079058 from Biobool

Category ELISA Kit

Human COLEC12 ELISA Kit - E079467 from Biobool

Category ELISA Kit

COLEC12 ELISA Kit (Human) (OKCA01167) - OKCA01167 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 0.078 ng/mL
Range 0.312 - 20 ng/mL
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