Gene Symbol | COLEC12 |
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Entrez Gene | 81035 |
Alt Symbol | CLP1, NSR2, SCARA4, SRCL |
Species | Human |
Gene Type | protein-coding |
Description | collectin sub-family member 12 |
Other Description | collectin placenta protein 1|collectin-12|hCL-P1|nurse cell scavenger receptor 2|scavenger receptor class A, member 4|scavenger receptor with C-type lectin |
Swissprots | Q9BY85 Q9BYH7 Q8TCR2 Q5KU26 Q8WZA4 Q6P9F2 |
Accessions | EAX01728 EAX01729 Q5KU26 AA903451 AB005145 BAB72147 AB034251 BAD83592 AB038518 BAB39147 AB052103 BAB39148 AL713657 CAD28466 BC060789 AAH60789 DB473908 JF432431 ADZ15648 XM_011525741 XP_011524043 NM_130386 NP_569057 NM_030781 |
Function | Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11162630}; Single-pass type II membrane protein {ECO:0000269|PubMed:11162630}. Note=Forms clusters on the cell surface. |
Tissue Specificity | Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:16868960}. |
Top Pathways | Phagosome |
Collectin-12 (COLEC12), Human, ELISA Kit - CSB-EL005762HU from ARP American Research Products
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Collectin-12 (COLEC12), Human, ELISA Kit - E01C1927 from ARP American Research Products
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Protein HEXIM1 (HEXIM1), Human, ELISA Kit - CSB-EL010318HU from ARP American Research Products
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Collectin 12 (COLEC12), ELISA Kit - MBS7246655 from MyBioSource
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collectin sub-family member 12, ELISA Kit - MBS907179 from MyBioSource
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Human Collectin-12(COLEC12) ELISA kit - CSB-EL005762HU from Cusabio
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Custom Human Collectin-12 ELISA - ELH-COLEC12 from RayBiotech
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Human Collectin-12 ELISA Kit - orb319923 from Biorbyt
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Human Collectin-12 ELISA - RAB1387 from Sigma-Aldrich
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Human Collectin-12 (COLEC12) ELISA Kit - EKC33234 from Biomatik
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Custom Human Collectin-12 ELISA - ELH-COLEC12-1 from RayBiotech
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Human CLP1 ELISA Kit - E079058 from Biobool
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Human COLEC12 ELISA Kit - E079467 from Biobool
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COLEC12 ELISA Kit (Human) (OKCA01167) - OKCA01167 from Aviva Systems Biology
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