| Gene Symbol |
MGAT4B
|
| Entrez Gene |
11282
|
| Alt Symbol |
GNT-IV, GNT-IVB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
|
| Other Description |
N-acetylglucosaminyltransferase IVb|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B|alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase|aminyltransferase|glcNAc-T IVb|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B
|
| Swissprots |
A8MPR0 Q9UQ53 Q96GH4 Q86TF1 Q9NSK6
|
| Accessions |
EAW53788 EAW53789 EAW53790 EAW53791 EAW53792 EAW53793 EAW53794 EAW53795 Q9UQ53 AB000624 BAA83464 AK023137 BAG51162 AK225490 AK225492 AL162067 CAB82404 AL537522 AY358984 AAQ89343 BC009464 AAH09464 BC051835 AAH51835 BQ882570 BQ939735 CN369872 NM_014275 NP_055090 NM_054013 NP_463459
|
| Function |
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Strongly overexpressed in pancreatic cancer. {ECO:0000269|PubMed:10372966}.
|
| Top Pathways |
N-Glycan biosynthesis
|