MGAT4B
| Gene Symbol | MGAT4B |
|---|---|
| Entrez Gene | 11282 |
| Alt Symbol | GNT-IV, GNT-IVB |
| Species | Human |
| Gene Type | protein-coding |
| Description | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B |
| Other Description | N-acetylglucosaminyltransferase IVb|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV|UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B|alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase|aminyltransferase|glcNAc-T IVb|mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B |
| Swissprots | A8MPR0 Q9UQ53 Q96GH4 Q86TF1 Q9NSK6 |
| Accessions | EAW53788 EAW53789 EAW53790 EAW53791 EAW53792 EAW53793 EAW53794 EAW53795 Q9UQ53 AB000624 BAA83464 AK023137 BAG51162 AK225490 AK225492 AL162067 CAB82404 AL537522 AY358984 AAQ89343 BC009464 AAH09464 BC051835 AAH51835 BQ882570 BQ939735 CN369872 NM_014275 NP_055090 NM_054013 NP_463459 |
| Function | Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Strongly overexpressed in pancreatic cancer. {ECO:0000269|PubMed:10372966}. |
| Top Pathways | N-Glycan biosynthesis |
GnT-IVB CRISPR/Cas9 KO Plasmid (h) - sc-410491 from Santa Cruz Biotechnology
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GnT-IVB HDR Plasmid (h) - sc-410491-HDR from Santa Cruz Biotechnology
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GnT-IVB Double Nickase Plasmid (h) - sc-410491-NIC from Santa Cruz Biotechnology
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GnT-IVB Double Nickase Plasmid (h2) - sc-410491-NIC-2 from Santa Cruz Biotechnology
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GnT-IVB CRISPR Activation Plasmid (h) - sc-410491-ACT from Santa Cruz Biotechnology
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GnT-IVB CRISPR Activation Plasmid (h2) - sc-410491-ACT-2 from Santa Cruz Biotechnology
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GnT-IVB Lentiviral Activation Particles (h) - sc-410491-LAC from Santa Cruz Biotechnology
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GnT-IVB Lentiviral Activation Particles (h2) - sc-410491-LAC-2 from Santa Cruz Biotechnology
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GnT-IVB siRNA (h) - sc-91754 from Santa Cruz Biotechnology
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GnT-IVB shRNA Plasmid (h) - sc-91754-SH from Santa Cruz Biotechnology
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GnT-IVB shRNA (h) Lentiviral Particles - sc-91754-V from Santa Cruz Biotechnology
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MGAT4B RNAi - H00011282-R02 from Novus Biologicals
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MGAT4B RNAi - H00011282-R01 from Novus Biologicals
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MISSION® esiRNA - EHU159521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13276 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13276 from Sigma-Aldrich
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MGAT4B siRNA (Human) - CRH7737 from Cohesion Biosciences
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shRNA set against Human MGAT4B (NM_014275.4) - SHH341387 from Creative biogene
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Human MGAT4B siRNA - orb268239 from Biorbyt
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MGAT4B shRNA Plasmid (Human) - CHH7737 from Cohesion Biosciences
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MGAT4B miRNA 3'UTR clone - MiUTR3H-06909 from Creative biogene
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MGAT4B miRNA 3'UTR clone - MiUTR3H-06910 from Creative biogene
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