Gene Symbol | KCNMB2 |
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Entrez Gene | 10242 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel subfamily M regulatory beta subunit 2 |
Other Description | BK channel beta subunit 2|BK channel subunit beta-2|MaxiK channel beta 2 subunit|MaxiK channel beta-subunit 2|big potassium channel beta subunit 2|calcium-activated potassium channel subunit beta-2|charybdotoxin receptor subunit beta-2|hCG1646471|hbeta2|k(VCA)beta-2|large conductance calcium-activated potassium channel beta 2 subunit|large-conductance Ca2+-activated K+ channel beta2 subunit|potassium large conductance calcium-activated channel, subfamily M, beta member 2|slo-beta-2 |
Swissprots | Q9Y691 |
Accessions | EAW78428 EAW78429 EAW78430 EAW78431 Q9Y691 AA904191 AB193524 BAG69602 AB193525 BAG69603 AB193526 BAG69604 AB193527 BAG69605 AB193528 BAG69606 AB193529 BAG69607 AB193530 BAG69608 AF099137 AAD23380 AF209747 AAF36562 AK298291 BAH12749 BC017825 AAH17825 BF434939 BG701449 BM983559 DA532966 DQ892011 ABM82937 DQ895200 ABM86126 XM_011512325 XP_011510627 XM_011512326 XP_011510628 XM_011512327 XP_011510629 XM_011512328 XP_011510630 NM_001278911 NP_001265840 NM_005832 NP_005823 NM_181361 NP_852006 |
Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. {ECO:0000269|PubMed:10097176, ECO:0000269|PubMed:10377337, ECO:0000269|PubMed:10692449}. |
Top Pathways | Vascular smooth muscle contraction, cGMP-PKG signaling pathway |
KCNMB2 (G-13) - sc-102631 from Santa Cruz Biotechnology
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KCNMB2 (N-14) - sc-102632 from Santa Cruz Biotechnology
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Anti-KCNMB2 antibody - ab136994 from Abcam
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Anti-KCNMB2 antibody - ab67700 from Abcam
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Anti-KCNMB2 antibody [S53-32] - ab94589 from Abcam
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Anti-KCNMB2 antibody - C-terminal - ab178051 from Abcam
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Anti-KCNMB2 antibody - N-terminal - ab83934 from Abcam
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Anti-KCNMB2 antibody - N-terminal - ab156596 from Abcam
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Anti-KCNMB2 Antibody (N-Terminus) - LS-C124413 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (clone S53-32) - LS-C152684 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (Ile186) - LS-C193144 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 488) - LS-C230890 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 390) - LS-C230887 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 565) - LS-C230891 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 594) - LS-C230892 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 633) - LS-C230893 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 655) - LS-C230894 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 680) - LS-C230895 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa140-189) - LS-C186661 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa151-200) - LS-C119795 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, AP) - LS-C230896 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, APC) - LS-C230897 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Atto 700) - LS-C230898 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32, Biotin) - LS-C230899 from LifeSpan Bioscience
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Anti-KCNMB2 Antibody (aa1-41, clone S53-32) - LS-C109028 from LifeSpan Bioscience
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