| Gene Symbol |
NCK2
|
| Entrez Gene |
8440
|
| Alt Symbol |
GRB4, NCKbeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NCK adaptor protein 2
|
| Other Description |
SH2/SH3 adaptor protein NCK-beta|cytoplasmic protein NCK2|growth factor receptor-bound protein 4|noncatalytic region of tyrosine kinase, beta
|
| Swissprots |
Q9BWN9 O43639 Q9UIC3 D3DVK1
|
| Accessions |
AAY14937 AAY24332 EAX01753 EAX01754 O43639 AF043119 AAC04831 AF047487 AAC80284 BC000103 AAH00103 BC007195 AAH07195 BC033176 BG480643 BM555604 BM920530 BU738133 CB959523 DB456958 XM_006712797 XP_006712860 XM_011511991 XP_011510293 XM_011511992 XP_011510294 NM_001004720 NP_001004720 NM_001004722 NP_001004722 NM_003581 NP_003572
|
| Function |
Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16835242}. Endoplasmic reticulum {ECO:0000269|PubMed:16835242}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway
|