NCK2

Gene Symbol	NCK2
Entrez Gene	8440
Alt Symbol	GRB4, NCKbeta
Species	Human
Gene Type	protein-coding
Description	NCK adaptor protein 2
Other Description	SH2/SH3 adaptor protein NCK-beta|cytoplasmic protein NCK2|growth factor receptor-bound protein 4|noncatalytic region of tyrosine kinase, beta
Swissprots	Q9BWN9 O43639 Q9UIC3 D3DVK1
Accessions	AAY14937 AAY24332 EAX01753 EAX01754 O43639 AF043119 AAC04831 AF047487 AAC80284 BC000103 AAH00103 BC007195 AAH07195 BC033176 BG480643 BM555604 BM920530 BU738133 CB959523 DB456958 XM_006712797 XP_006712860 XM_011511991 XP_011510293 XM_011511992 XP_011510294 NM_001004720 NP_001004720 NM_001004722 NP_001004722 NM_003581 NP_003572
Function	Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16835242}. Endoplasmic reticulum {ECO:0000269|PubMed:16835242}.
Tissue Specificity	Ubiquitous.
Top Pathways	Axon guidance, T cell receptor signaling pathway, Pathogenic Escherichia coli infection, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NCK2 CRISPR/Cas9 KO Plasmid (h) - sc-403855 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 HDR Plasmid (h) - sc-403855-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 Double Nickase Plasmid (h) - sc-403855-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 Double Nickase Plasmid (h2) - sc-403855-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 CRISPR Activation Plasmid (h) - sc-403855-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 CRISPR Activation Plasmid (h2) - sc-403855-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 Lentiviral Activation Particles (h) - sc-403855-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 Lentiviral Activation Particles (h2) - sc-403855-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NCK2 siRNA (h) - sc-36018 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NCK2 shRNA Plasmid (h) - sc-36018-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NCK2 shRNA (h) Lentiviral Particles - sc-36018-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NCK2 RNAi - H00008440-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

NCK2 RNAi - H00008440-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

NCK2 RNAi - H00008440-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU057301 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15019 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15019 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

NCK2 siRNA (Human) - CRH5530 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NCK2 (NM_003581.4) - SHH349980 from Creative biogene Category siRNA Species Reactivities Human

Human NCK2 siRNA - orb266032 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NCK2 shRNA Plasmid (Human) - CHH5530 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NCK2 miRNA 3'UTR clone - MiUTR1H-06675 from Creative biogene Species Reactivities Human

NCK2 miRNA 3'UTR clone - MiUTR1H-06676 from Creative biogene Species Reactivities Human

NCK2 miRNA 3'UTR clone - MiUTR1H-06677 from Creative biogene Species Reactivities Human

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