AK2

Gene Symbol AK2
Entrez Gene 204
Alt Symbol ADK2, AK 2
Species Human
Gene Type protein-coding
Description adenylate kinase 2
Other Description AK 2|ATP-AMP transphosphorylase 2|ATP:AMP phosphotransferase|adenylate kinase 2, mitochondrial|adenylate kinase isoenzyme 2, mitochondrial|adenylate monophosphate kinase
Swissprots Q5EB54 Q8TCY2 Q8TCY3 B4DHH7 P54819 Q16856 A8K6L1 B4DL64 Q5TIF7
Accessions EAX07483 EAX07484 EAX07485 EAX07486 P54819 AB005621 BAC16747 AB005622 BAC16748 AB451267 BAG70081 AB451394 BAG70208 AK023758 AK291676 BAF84365 AK295105 BAG58139 AK296863 BAG59426 AK297036 BAG59564 AK307731 AY080899 AAL87027 AY080900 AAL87028 BC009405 AAH09405 BC026705 BC070127 AAH70127 BC090040 AAH90040 BX504559 DB206302 DC422465 U39945 AAC52061 U54645 AAC13881 U84371 AAB41790 XM_011540967 XP_011539269 XR_246248 XR_946575 NM_001199199 NP_001186128 NM_001625 NP_001616 NM_013411 NP_037543 NR_037591 NR_037592
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP- Rule:MF_03168, ECO:0000269|PubMed:19043416}.
Subcellular Location Mitochondrion intermembrane space.
Tissue Specificity Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}.
Top Pathways Purine metabolism

Adenylate kinase 2, mitochondrial (AK2), Human, ELISA Kit - E01A1348 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7213872 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 ng/mL.

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7223095 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7224399 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7240271 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7225683 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7243860 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7253410 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7219376 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7226039 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7241437 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7205104 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Adenylate kinase 2, mitochondrial (AK2), ELISA Kit - MBS7211519 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human AK2 ELISA Kit - E000867 from Biobool

Category ELISA Kit
Sensitivity 1.0 ng/mL.

anti-AK2 antibody - ARG54907 from Arigo Biolaboratories

Category ELISA Kit

anti-AK2 antibody [7E7] - ARG57157 from Arigo Biolaboratories

Category ELISA Kit

anti-AK2 antibody - ARG54805 from Arigo Biolaboratories

Category ELISA Kit

Adenylate kinase 2, ELISA Kit - MBS285524 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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