AK2

Gene Symbol	AK2
Entrez Gene	204
Alt Symbol	ADK2, AK 2
Species	Human
Gene Type	protein-coding
Description	adenylate kinase 2
Other Description	AK 2|ATP-AMP transphosphorylase 2|ATP:AMP phosphotransferase|adenylate kinase 2, mitochondrial|adenylate kinase isoenzyme 2, mitochondrial|adenylate monophosphate kinase
Swissprots	Q5EB54 Q8TCY2 Q8TCY3 B4DHH7 P54819 Q16856 A8K6L1 B4DL64 Q5TIF7
Accessions	EAX07483 EAX07484 EAX07485 EAX07486 P54819 AB005621 BAC16747 AB005622 BAC16748 AB451267 BAG70081 AB451394 BAG70208 AK023758 AK291676 BAF84365 AK295105 BAG58139 AK296863 BAG59426 AK297036 BAG59564 AK307731 AY080899 AAL87027 AY080900 AAL87028 BC009405 AAH09405 BC026705 BC070127 AAH70127 BC090040 AAH90040 BX504559 DB206302 DC422465 U39945 AAC52061 U54645 AAC13881 U84371 AAB41790 XM_011540967 XP_011539269 XR_246248 XR_946575 NM_001199199 NP_001186128 NM_001625 NP_001616 NM_013411 NP_037543 NR_037591 NR_037592
Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP- Rule:MF_03168, ECO:0000269|PubMed:19043416}.
Subcellular Location	Mitochondrion intermembrane space.
Tissue Specificity	Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AK2-Over-expression-Lysate - LY10134a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

AK2 293T Cell Transient Overexpression Lysate(Denatured) - H00000204-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

AK2 overexpression lysate - LY419835 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AK2 293 Cell Lysate - 409290 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

AK2 Overexpression Lysate (Denatured) - H00000204-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

AK2 Overexpression Lysate (Native) - NBL1-07418 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

AK2 (h): 293T Lysate - sc-111620 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

AK2 Over-expression Lysate Product - GWB-25961D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human AK2 / Adenylate kinase 2 Insect Cell Lysate (WB positive control) - 13146-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human AK2 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175109 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Panoply™ Human AK2 Knockdown Stable Cell Line - CSC-DC000424 from Creative biogene Category Cell Line Species Human

AK2 KO Cell Lysate-HEK293T - CLKO-0897 from Creative biogene Category Cell Lysate

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