AK2

Gene Symbol	AK2
Entrez Gene	204
Alt Symbol	ADK2, AK 2
Species	Human
Gene Type	protein-coding
Description	adenylate kinase 2
Other Description	AK 2|ATP-AMP transphosphorylase 2|ATP:AMP phosphotransferase|adenylate kinase 2, mitochondrial|adenylate kinase isoenzyme 2, mitochondrial|adenylate monophosphate kinase
Swissprots	Q5EB54 Q8TCY2 Q8TCY3 B4DHH7 P54819 Q16856 A8K6L1 B4DL64 Q5TIF7
Accessions	EAX07483 EAX07484 EAX07485 EAX07486 P54819 AB005621 BAC16747 AB005622 BAC16748 AB451267 BAG70081 AB451394 BAG70208 AK023758 AK291676 BAF84365 AK295105 BAG58139 AK296863 BAG59426 AK297036 BAG59564 AK307731 AY080899 AAL87027 AY080900 AAL87028 BC009405 AAH09405 BC026705 BC070127 AAH70127 BC090040 AAH90040 BX504559 DB206302 DC422465 U39945 AAC52061 U54645 AAC13881 U84371 AAB41790 XM_011540967 XP_011539269 XR_246248 XR_946575 NM_001199199 NP_001186128 NM_001625 NP_001616 NM_013411 NP_037543 NR_037591 NR_037592
Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP- Rule:MF_03168, ECO:0000269|PubMed:19043416}.
Subcellular Location	Mitochondrion intermembrane space.
Tissue Specificity	Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AK2 (C-20) - sc-17623 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AK2 (F-2) - sc-374095 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

AK2 (H-65) - sc-28786 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

AK2 (N-20) - sc-17621 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-AK2 antibody - ab37594 from Abcam Prices $369.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AK2 antibody - ab152094 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AK2 antibody - ab71729 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AK2 antibody - ab93856 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AK2 antibody - ab167494 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-AK2 antibody [EPR11387(B)] - ab157206 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11387(B)

Anti-AK2 antibody [EPR11388(B)] - ab166901 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11388(B)

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus) - LS-C80807 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, AP) - LS-C274913 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, Biotin) - LS-C274915 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, APC) - LS-C274914 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (aa143-192) - LS-C116319 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody - LS-C137291 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (clone 3F1) - LS-C196634 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F1

Anti-AK2 / Adenylate Kinase 2 Antibody (Internal) - LS-C137126 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, FITC) - LS-C274916 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, Azide-free, HRP) - LS-C274917 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (C-Terminus, APC) - LS-C274920 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (C-Terminus, AP) - LS-C274919 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (N-Terminus, PE) - LS-C274918 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AK2 / Adenylate Kinase 2 Antibody (C-Terminus, Biotin) - LS-C274921 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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