AK2
| Gene Symbol | AK2 |
|---|---|
| Entrez Gene | 204 |
| Alt Symbol | ADK2, AK 2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adenylate kinase 2 |
| Other Description | AK 2|ATP-AMP transphosphorylase 2|ATP:AMP phosphotransferase|adenylate kinase 2, mitochondrial|adenylate kinase isoenzyme 2, mitochondrial|adenylate monophosphate kinase |
| Swissprots | Q5EB54 Q8TCY2 Q8TCY3 B4DHH7 P54819 Q16856 A8K6L1 B4DL64 Q5TIF7 |
| Accessions | EAX07483 EAX07484 EAX07485 EAX07486 P54819 AB005621 BAC16747 AB005622 BAC16748 AB451267 BAG70081 AB451394 BAG70208 AK023758 AK291676 BAF84365 AK295105 BAG58139 AK296863 BAG59426 AK297036 BAG59564 AK307731 AY080899 AAL87027 AY080900 AAL87028 BC009405 AAH09405 BC026705 BC070127 AAH70127 BC090040 AAH90040 BX504559 DB206302 DC422465 U39945 AAC52061 U54645 AAC13881 U84371 AAB41790 XM_011540967 XP_011539269 XR_246248 XR_946575 NM_001199199 NP_001186128 NM_001625 NP_001616 NM_013411 NP_037543 NR_037591 NR_037592 |
| Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP- Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| Subcellular Location | Mitochondrion intermembrane space. |
| Tissue Specificity | Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). {ECO:0000269|PubMed:19043417}. |
| Top Pathways | Purine metabolism |
AK2 CRISPR/Cas9 KO Plasmid (h) - sc-404166 from Santa Cruz Biotechnology
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AK2 HDR Plasmid (h) - sc-404166-HDR from Santa Cruz Biotechnology
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AK2 Double Nickase Plasmid (h) - sc-404166-NIC from Santa Cruz Biotechnology
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AK2 Double Nickase Plasmid (h2) - sc-404166-NIC-2 from Santa Cruz Biotechnology
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AK2 CRISPR Activation Plasmid (h) - sc-404166-ACT from Santa Cruz Biotechnology
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AK2 CRISPR Activation Plasmid (h2) - sc-404166-ACT-2 from Santa Cruz Biotechnology
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AK2 Lentiviral Activation Particles (h) - sc-404166-LAC from Santa Cruz Biotechnology
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AK2 Lentiviral Activation Particles (h2) - sc-404166-LAC-2 from Santa Cruz Biotechnology
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AK2 siRNA (h) - sc-38906 from Santa Cruz Biotechnology
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AK2 shRNA Plasmid (h) - sc-38906-SH from Santa Cruz Biotechnology
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AK2 shRNA (h) Lentiviral Particles - sc-38906-V from Santa Cruz Biotechnology
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AK2 RNAi - H00000204-R04 from Novus Biologicals
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AK2 RNAi - H00000204-R05 from Novus Biologicals
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AK2 RNAi - H00000204-R06 from Novus Biologicals
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MISSION® esiRNA - EHU114101 from Sigma-Aldrich
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MISSION® siRNA - SIHK0076 from Sigma-Aldrich
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MISSION® siRNA - SIHK0078 from Sigma-Aldrich
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MISSION® siRNA - SIHK0077 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2995 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2995 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11834 from Sigma-Aldrich
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AK2 siRNA (Human) - CRH0141 from Cohesion Biosciences
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AK2 - MBS8205649 from MyBioSource
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shRNA set against Human AK2 (NM_001625.3) - SHH234094 from Creative biogene
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Human AK2 siRNA - orb260643 from Biorbyt
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